A Toxin-Conjugated Recombinant Protein Targeting gp120 and gp41 for Inactivating HIV-1 Virions and Killing Latency-Reversing Agent-Reactivated Latent Cells
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DOI: 10.1128/mbio.03384-21
Abstract: Although HIV-1 replication was successfully controlled by antiretroviral drugs, cure strategy for HIV-1/AIDS is still lacking. The long-lived HIV reservoir is considered one of the major obstacles to an HIV/AIDS cure. ABSTRACT Application of the… read more here.
Keywords: latent cells; hiv virions; toxin; hiv ... See more keywords
Active PD-L1 incorporation within HIV virions functionally impairs T follicular helper cells
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DOI: 10.1371/journal.ppat.1010673
Abstract: The limited development of broadly neutralizing antibodies (BnAbs) during HIV infection is classically attributed to an inadequate B-cell help brought by functionally impaired T follicular helper (Tfh) cells. However, the determinants of Tfh-cell functional impairment… read more here.
Keywords: hiv virions; follicular helper; active incorporation; tfh cell ... See more keywords
Host Molecule Incorporation into HIV Virions, Potential Influences in HIV Pathogenesis
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DOI: 10.3390/v14112523
Abstract: During the last phase of HIV viral production, nascent HIV virions acquire a fraction of the cellular lipid membrane to create the external lipid envelope, a process by which cellular proteins present on the surface… read more here.
Keywords: hiv virions; hiv pathogenesis; hiv; host molecule ... See more keywords