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   Articles with "hk2" as a keyword



MicroRNA‐384‐3p inhibits retinal neovascularization through targeting hexokinase 2 in mice with diabetic retinopathy

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recommendations! Published in 2018 at "Journal of Cellular Physiology"

DOI: 10.1002/jcp.26871

Abstract: Diabetic retinopathy (DR) presents a microvascular complication of diabetes, which may contribute to visual impairment. The treatment of DR is still controversial. Accumulating studies have reported the role of microRNAs (miRs) in DR. This study… read more here.

Keywords: diabetic retinopathy; mir 384; mice; retinal neovascularization ... See more keywords

NK007 helps in mitigating paclitaxel resistance through p38MAPK activation and HK2 degradation in ovarian cancer

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recommendations! Published in 2019 at "Journal of Cellular Physiology"

DOI: 10.1002/jcp.28278

Abstract: Ovarian cancer resistance to available medicines is a huge challenge in dire need of a solution, which makes its recurrence and mortality rate further exacerbated. A promising approach to overcome chemoresistance is drug screening from… read more here.

Keywords: resistance; ovarian cancer; nk007; cancer ... See more keywords

MiR-216a-5p/Hexokinase 2 axis regulates uveal melanoma growth through modulation of Warburg effect.

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recommendations! Published in 2018 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2018.05.069

Abstract: Hexokinase-2 (HK2), the initial as well as the rate-limiting step in glycolysis, is overexpressed in many human cancers, and correlates with poor clinical outcomes. Aerobic glycolysis is a hallmark of cancer, and drugs targeting its… read more here.

Keywords: uveal melanoma; mir 216a; hexokinase; hk2 ... See more keywords

Rabeprazole Suppresses Cell Proliferation in Gastric Epithelial Cells by Targeting STAT3-mediated Glycolysis.

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recommendations! Published in 2021 at "Biochemical pharmacology"

DOI: 10.1016/j.bcp.2021.114525

Abstract: The dysregulation of glycolysis leads to serials of disease. Rabeprazole is a representative of proton pump inhibitors and widely used in anti-ulcer treatment. However, the function of Rabeprazole on glycolysis in gastric epithelial cells remained… read more here.

Keywords: gastric epithelial; glycolysis; cell proliferation; rabeprazole ... See more keywords

Microbial regulation of hexokinase 2 links mitochondrial metabolism and cell death in colitis.

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recommendations! Published in 2021 at "Cell metabolism"

DOI: 10.1016/j.cmet.2021.11.004

Abstract: Hexokinases (HK) catalyze the first step of glycolysis limiting its pace. HK2 is highly expressed in gut epithelium, contributes to immune responses, and is upregulated during inflammation. We examined the microbial regulation of HK2 and… read more here.

Keywords: microbial regulation; cell death; colitis; hk2 ... See more keywords

Molecular docking and simulation studies of phytocompounds derived from Centella asiatica and Andrographis paniculata against hexokinase II as mitocan agents.

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recommendations! Published in 2021 at "Mitochondrion"

DOI: 10.1016/j.mito.2021.09.013

Abstract: Hexokinase II (HK2), a glycolytic enzyme is commonly overexpressed in most cancer types. The overexpression of HK2 is reported to promote the survival of cancer cells by facilitating the constant ATP generation and protecting the… read more here.

Keywords: andrographis paniculata; hexokinase; centella asiatica; cancer ... See more keywords

Inhibiting Glycolysis and Disrupting the Mitochondrial HK2-VDAC1 Protein-Protein Interaction Using a Bifunctional Lonidamine-Conjugated Metal Probe for Combating Triple-Negative Breast Cancer.

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recommendations! Published in 2025 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.5c04233

Abstract: Triple-negative breast cancer (TNBC) relies primarily on aerobic glycolysis for energy and rapid cancer cell proliferation. Hexokinase 2 (HK2), a key enzyme regulating glycolysis, is overexpressed in TNBC, promoting tumor cell proliferation and apoptosis resistance… read more here.

Keywords: cancer; vdac1; hk2 vdac1; hk2 ... See more keywords

The catalytic inactivation of the N-half of human hexokinase 2 and structural and biochemical characterization of its mitochondrial conformation

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recommendations! Published in 2018 at "Bioscience Reports"

DOI: 10.1042/bsr20171666

Abstract: The high proliferation rate of tumor cells demands high energy and metabolites that are sustained by a high glycolytic flux known as the ‘Warburg effect’. The activation and further metabolism of glucose is initiated by… read more here.

Keywords: structural biochemical; human hexokinase; conformation; half ... See more keywords

N6-methyladenosine methyltransferase KIAA1429 elevates colorectal cancer aerobic glycolysis via HK2-dependent manner

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recommendations! Published in 2022 at "Bioengineered"

DOI: 10.1080/21655979.2022.2065952

Abstract: ABSTRACT Emerging evidence has emphasized the critical roles played by N6-methyladenosine RNA (m6A) modification in colorectal carcinoma (CRC) initiation and progression. However, the roles and mechanism of m6A and KIAA1429 in CRC progression require further… read more here.

Keywords: manner; aerobic glycolysis; crc; kiaa1429 ... See more keywords

Tristetraprolin-mediated hexokinase 2 expression regulation contributes to glycolysis in cancer cells

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recommendations! Published in 2019 at "Molecular Biology of the Cell"

DOI: 10.1091/mbc.e18-09-0606

Abstract: Hexokinase 2 (HK2) catalyzes the first step of glycolysis and is up-regulated in cancer cells. The mechanism has not been fully elucidated. Tristetraprolin (TTP) is an AU-rich element (ARE)-binding protein that inhibits the expression of… read more here.

Keywords: expression; hk2; cancer cells; cancer ... See more keywords
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Down-regulating HK2 inhibits proliferation of endometrial stromal cells through a noncanonical pathway involving phosphorylation of STAT1 in endometriosis.

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recommendations! Published in 2022 at "Biology of reproduction"

DOI: 10.1093/biolre/ioac081

Abstract: BACKGROUND Endometriosis is a benign gynecologic disease that causes chronic pelvic pain, dysmenorrhea and infertility and shares several characteristics with malignant tumors, afflicting women of reproductive age. Hexokinase 2 (HK2) plays an essential role as… read more here.

Keywords: hk2; proliferation endometrial; endometriosis; stromal cells ... See more keywords