Inhibition of N-glycosylation by glucosamine hydrochloride inhibits TGF-β1-induced LOXL2 secretion.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cellular biochemistry"
DOI: 10.1002/jcb.30404
Abstract: Kidney fibrosis is closely associated with the progression of chronic kidney disease (CKD). Furthermore, copper-containing secretory amine oxidases, such as lysyl oxidase (LOX) and LOX-like 1-4 (LOXL1-4), play pivotal roles in the regulation of extracellular… read more here.
Keywords: hk2 cells; glucosamine hydrochloride; loxl2 secretion; lox enzymes ... See more keywords
USF2 exacerbates sepsis-induced acute kidney injury and ferroptosis through LPCAT3-mediated NRF2/HO-1/GPX4 pathway.
Sign Up to like & getrecommendations! Published in 2025 at "Shock"
DOI: 10.1097/shk.0000000000002588
Abstract: ABSTRACT Background: Sepsis-acute kidney injury (AKI) is a common complication in critically ill patients with a very high mortality rate. Lysophosphatidylcholine acyltransferase 3 (LPCAT3) is crucial in lipid metabolism; however, its role in the pathogenesis… read more here.
Keywords: sepsis aki; lpcat3; nrf2 gpx4; hk2 cells ... See more keywords
497-P: Fyn-Dependent Tyrosine Phosphorylation of Tgm2 Modulates p53-Tgm2-p62 Complex in Renal Proximal Tubular Epithelial Cells
Sign Up to like & getrecommendations! Published in 2019 at "Diabetes"
DOI: 10.2337/db19-497-p
Abstract: Diabetic kidney disease (DKD) is one of the major diabetic complications, the leading cause of the end stage renal disease (ESRD). Recently autophagy, which is also implicated in diabetes and insulin resistance, was shown to… read more here.
Keywords: p62; tgm2; hk2 cells; fyn ... See more keywords
The Effects of Glyphosate and Roundup® Herbicides on the Kidneys’ Cortex and the Medulla and on Renal Tubular Cells’ Mitochondrial Respiration and Oxidative Stress
Sign Up to like & getrecommendations! Published in 2025 at "Molecules"
DOI: 10.3390/molecules30112335
Abstract: Glyphosate (GP) and its derivatives are present in almost all environments and suspected to induce acute and chronic kidney injuries. This public health issue is relatively underexplored. We therefore conducted an investigation on rats and… read more here.
Keywords: cortex medulla; mitochondrial respiration; oxidative stress; medulla ... See more keywords
Inhibition of Fatty Acid β-Oxidation by Fatty Acid Binding Protein 4 Induces Ferroptosis in HK2 Cells Under High Glucose Conditions
Sign Up to like & getrecommendations! Published in 2023 at "Endocrinology and Metabolism"
DOI: 10.3803/enm.2022.1604
Abstract: Background Ferroptosis, which is caused by an iron-dependent accumulation of lipid hydroperoxides, is a type of cell death linked to diabetic kidney disease (DKD). Previous research has shown that fatty acid binding protein 4 (FABP4)… read more here.
Keywords: hk2 cells; acid oxidation; fatty acid; ferroptosis hk2 ... See more keywords