Characterization and Inhibition of Human Hexokinase Domain Containing Protein 1 Reveals an Enzyme with Unique Catalytic and Regulatory Traits.
Sign Up to like & getrecommendations! Published in 2025 at "ACS chemical biology"
DOI: 10.1021/acschembio.5c00715
Abstract: Hexokinase domain containing protein 1 (HKDC1) is a recently discovered fifth human hexokinase isozyme that is significantly upregulated in several disease states, including lung and liver cancers. Cellular studies suggest that HKDC1 is a low… read more here.
Keywords: human hexokinase; hexokinase; hkdc1; inhibition ... See more keywords
HKDC1 upregulation promotes glycolysis and disease progression, and confers chemoresistance onto gastric cancer
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Science"
DOI: 10.1111/cas.15692
Abstract: There is increasing evidence that hexokinase is involved in cell proliferation and migration. However, the function of the hexokinase domain containing protein‐1 (HKDC1) in gastric cancer (GC) remains unclear. Immunohistochemistry analysis and big data mining… read more here.
Keywords: upregulation promotes; hkdc1 upregulation; hkdc1; gastric cancer ... See more keywords
HKDC1 Silencing Inhibits Proliferation and Glycolysis of Gastric Cancer Cells
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Oncology"
DOI: 10.1155/2023/3876342
Abstract: Gastric cancer (GC) is the third most lethal and fifth most common cancer in the world. In a variety of cancers, the hexokinase domain component 1 (HKDC1) is carcinogenic. This study was to investigate into… read more here.
Keywords: proliferation glycolysis; hkdc1; cancer; gastric cancer ... See more keywords
Enterocyte HKDC1 Modulates Intestinal Glucose Absorption in Male Mice Fed a High-fat Diet
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DOI: 10.1210/endocr/bqac050
Abstract: Abstract Hexokinase domain containing protein-1, or HKDC1, is a widely expressed hexokinase that is genetically associated with elevated 2-hour gestational blood glucose levels during an oral glucose tolerance test, suggesting a role for HKDC1 in… read more here.
Keywords: mice fed; hkdc1; high fat; fat diet ... See more keywords
LPS mediates cuproptosis and inflammation in THP-1 macrophages through HKDC1.
Sign Up to like & getrecommendations! Published in 2025 at "Acta biochimica et biophysica Sinica"
DOI: 10.3724/abbs.2025089
Abstract: Cuproptosis is a recently identified form of copper-driven cell death characterized by the aggregation of acylated proteins and proteotoxic stress in the mitochondrial tricarboxylic acid cycle, which plays a role in inflammation. Recent studies suggest… read more here.
Keywords: mediates cuproptosis; hkdc1; cuproptosis; lps mediates ... See more keywords
A comprehensive prognostic and immunological analysis of hexokinase domain containing protein-1 (HKDC1) in pan-cancer
Sign Up to like & getrecommendations! Published in 2025 at "PeerJ"
DOI: 10.7717/peerj.19083
Abstract: Background Currently, research on the role of hexokinase domain-containing protein-1 (HKDC1) in neoplasm metabolism remains sparse. This study seeks to conduct a thorough investigation of HKDC1’s potential functions across thirty-three different tumor types, utilizing data… read more here.
Keywords: cancer; hkdc1; analysis; domain containing ... See more keywords