Potassium ions promote hexokinase-II dependent glycolysis
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DOI: 10.1016/j.isci.2021.102346
Abstract: Summary High expression levels of mitochondria-associated hexokinase-II (HKII) represent a hallmark of metabolically highly active cells such as fast proliferating cancer cells. Typically, the enzyme provides a crucial metabolic switch towards aerobic glycolysis. By imaging… read more here.
Keywords: glycolysis; promote hexokinase; dependent glycolysis; ions promote ... See more keywords
Structural basis of complex formation between mitochondrial anion channel VDAC1 and Hexokinase-II
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DOI: 10.1038/s42003-021-02205-y
Abstract: Complex formation between hexokinase-II (HKII) and the mitochondrial VDAC1 is crucial to cell growth and survival. We hypothesize that HKII first inserts into the outer membrane of mitochondria (OMM) and then interacts with VDAC1 on… read more here.
Keywords: binary complex; complex formation; vdac1; formation ... See more keywords