Pi5 and Pi6, two undescribed peptides from the venom of the scorpion Pandinus imperator and their effects on K+‐channels
Sign Up to like & getrecommendations! Published in 2017 at "Toxicon"
DOI: 10.1016/j.toxicon.2017.05.011
Abstract: Abstract This work reports the isolation, chemical and functional characterization of two previously unknown peptides purified from the venom of the scorpion Pandinus imperator, denominated Pi5 and Pi6. Pi5 is a classical K+‐channel blocking peptide… read more here.
Keywords: hkv1 hkv1; pandinus imperator; scorpion; pi5 pi6 ... See more keywords
Open channel block of Kv1.5 channels by HMQ1611
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DOI: 10.3389/fphar.2022.965086
Abstract: Kv1.5 channels conduct the ultra-rapid delayed rectifier potassium current (I Kur). Pharmacological blockade of human Kv1.5 (hKv1.5) has been regarded as an effective treatment of re-entrant based atrial fibrillation, because Kv1.5 is highly expressed in… read more here.
Keywords: kv1; open channel; hkv1; channels hmq1611 ... See more keywords
Characterization and Chemical Synthesis of Cm39 (α-KTx 4.8): A Scorpion Toxin That Inhibits Voltage-Gated K+ Channel KV1.2 and Small- and Intermediate-Conductance Ca2+-Activated K+ Channels KCa2.2 and KCa3.1
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DOI: 10.3390/toxins15010041
Abstract: A novel peptide, Cm39, was identified in the venom of the scorpion Centruroides margaritatus. Its primary structure was determined. It consists of 37 amino acid residues with a MW of 3980.2 Da. The full chemical… read more here.
Keywords: voltage; toxin; hkv1; scorpion ... See more keywords