HL156A, a novel pharmacological agent with potent adenosine-monophosphate-activated protein kinase (AMPK) activator activity ameliorates renal fibrosis in a rat unilateral ureteral obstruction model
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DOI: 10.1371/journal.pone.0201692
Abstract: Background Renal fibrosis is characterized by excessive production and deposition of extracellular matrix (ECM), which leads to progressive renal failure. Adenosine-monophosphate-activated protein kinase (AMPK) is a highly conserved kinase that plays a key role in… read more here.
Keywords: hl156a; kinase; renal fibrosis; ampk activator ... See more keywords
Metformin Derivative HL156A Reverses Multidrug Resistance by Inhibiting HOXC6/ERK1/2 Signaling in Multidrug-Resistant Human Cancer Cells
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DOI: 10.3390/ph13090218
Abstract: Multidrug resistance is a significant clinical crisis in cancer treatment and has been linked to the cellular expression of multidrug efflux transporters. The aim of this study was to examine the effects and mechanisms of… read more here.
Keywords: hl156a; cancer cells; derivative hl156a; multidrug resistance ... See more keywords