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   Articles with "hl60" as a keyword



Knockdown of LncRNA‐UCA1 suppresses chemoresistance of pediatric AML by inhibiting glycolysis through the microRNA‐125a/hexokinase 2 pathway

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recommendations! Published in 2018 at "Journal of Cellular Biochemistry"

DOI: 10.1002/jcb.26899

Abstract: Dysregulation of lncRNAs is implicated in chemoresistance in varieties of tumor including acute myeloid leukemia (AML). LncRNA urothelial carcinoma‐associated 1 (UCA1) was reported to play an oncogenic role in AML. However, whether UCA1 was involved… read more here.

Keywords: glycolysis; chemoresistance; adr; aml ... See more keywords
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Antitumour effects of selected plant polyphenols, gallic acid and ellagic acid, on sensitive and multidrug‐resistant leukaemia HL60 cells

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recommendations! Published in 2019 at "Phytotherapy Research"

DOI: 10.1002/ptr.6317

Abstract: The aim of this study was to examine the antitumour effects of plant phenolic acids, gallic acid (GA) and ellagic acid (EA), on human promyelocytic leukaemia sensitive HL60 cell line and its resistant sublines exhibiting… read more here.

Keywords: gallic acid; antitumour effects; hl60 cells; acid ellagic ... See more keywords
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Bioreductive Activation of Antitumour Drugs, Doxorubicin and Pirarubicin, Does Not Affect Their Ability to Induce Apoptosis of Sensitive and Multidrug Resistant Leukaemia HL60 Cells

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recommendations! Published in 2021 at "AntiCancer Research"

DOI: 10.21873/anticanres.14900

Abstract: Background/Aim: Clinical significance of antitumour drugs is limited by multidrug resistance (MDR). We examined the effect of bioreductive activation of the anthracyclines, doxorubicin (DOX) and pirarubicin (PIRA), by cytochrome P450 reductase (CPR) on triggering apoptosis… read more here.

Keywords: bioreductive activation; apoptosis; leukaemia; antitumour drugs ... See more keywords
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A Comparison of Doxorubicin-Resistant Colon Cancer LoVo and Leukemia HL60 Cells: Common Features, Different Underlying Mechanisms.

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recommendations! Published in 2021 at "Current issues in molecular biology"

DOI: 10.3390/cimb43010014

Abstract: Chemoresistance causes cancer relapse and metastasis, thus remaining the major obstacle to cancer therapy. While some light has been shed on the underlying mechanisms, it is clear that chemoresistance is a multifaceted problem strictly interconnected… read more here.

Keywords: underlying mechanisms; colon cancer; leukemia hl60; cancer ... See more keywords