Genetics and Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis: What Have We Learned?
Sign Up to like & getrecommendations! Published in 2017 at "JAMA ophthalmology"
DOI: 10.1001/jamaophthalmol.2017.0136
Abstract: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are part of a spectrum of severe cutaneous reactions affecting skin and mucous membranes.1 Affected patients usually develop a prodrome of fever and malaise, followed by the… read more here.
Keywords: sjs ten; genetics; johnson syndrome; sjs ... See more keywords
Pretransplant active disease status and HLA class II mismatching are associated with increased incidence and severity of cytokine release syndrome after haploidentical transplantation with posttransplant cyclophosphamide
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Medicine"
DOI: 10.1002/cam4.2607
Abstract: Cytokine release syndrome (CRS) represents a life‐threatening side effect after haploidentical stem cell transplantation (Haplo‐SCT) with posttransplant cyclophosphamide (PT‐Cy). Factors predictive of CRS development is still a matter of debate. We retrospectively analyzed 102 consecutive… read more here.
Keywords: disease status; crs; disease; hla ... See more keywords
Reducing severe cutaneous adverse and type B adverse drug reactions using pre‐stored human leukocyte antigen genotypes
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Translational Allergy"
DOI: 10.1002/clt2.12098
Abstract: Abstract Background Several type B adverse drug reactions (ADRs), especially severe cutaneous adverse reactions (SCARs), are associated with particular human leukocyte antigen (HLA) genotypes. However, pre‐stored HLA information obtained from other clinical workups has not… read more here.
Keywords: hla hla; hla; pre stored; risk ... See more keywords
Molecular disparity of HLA‐DPB1 is associated with the development of subsequent solid cancer after allogeneic hematopoietic stem cell transplantation
Sign Up to like & getrecommendations! Published in 2023 at "Cancer"
DOI: 10.1002/cncr.34671
Abstract: An increased incidence of subsequent solid cancers (SSCs) has been reported in long‐term survivors of allogeneic hematopoietic stem cell transplantation (allo‐HSCT), and SSC is associated with inferior mortality and morbidity. Previous studies showed that the… read more here.
Keywords: allogeneic hematopoietic; stem cell; hla; subsequent solid ... See more keywords
Monocyte HLA‐DR Measurement by Flow Cytometry in COVID‐19 Patients: An Interim Review
Sign Up to like & getrecommendations! Published in 2020 at "Cytometry Part A"
DOI: 10.1002/cyto.a.24249
Abstract: Several months after the sudden emergence of SARS‐CoV‐2 and COVID‐19, the understanding of the appropriate host immune response to a virus totally unknown of human immune surveillance is still of major importance. By international definition,… read more here.
Keywords: covid patients; hla; measurement; cytometry ... See more keywords
HLA‐DRB1*15:01 is a co‐receptor for Epstein–Barr virus, linking genetic and environmental risk factors for multiple sclerosis
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Immunology"
DOI: 10.1002/eji.202149179
Abstract: Figure 1. Synopsis of the experimental strategy. The CD21-positive, human leukocyte antigen (HLA) class II-negative lymphoblastoid cell line 721.174 was co-transfected with plasmids encoding the HLA-DR α-chain HLA-DRA*01:01 and the HLA-DR β-chain HLA-DRB1*01:01 or HLADRB1*15:01.… read more here.
Keywords: epstein barr; hla drb1; hla; drb1 receptor ... See more keywords
Flow cytometry‐based high‐throughput RNAi screening for miRNAs regulating MHC class II HLA‐DR surface expression
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202149735
Abstract: HLA‐DR isotype is a MHC‐II cell‐surface receptor found on APCs and plays a key role in initiating immune responses. In severely immunocompromised patients with conditions like sepsis, the number of HLA‐DR molecules expressed on leukocytes… read more here.
Keywords: based high; flow cytometry; hla; surface ... See more keywords
HLA‐HD: An accurate HLA typing algorithm for next‐generation sequencing data
Sign Up to like & getrecommendations! Published in 2017 at "Human Mutation"
DOI: 10.1002/humu.23230
Abstract: The accurate typing of human leukocyte antigen (HLA) alleles is critical for a variety of medical applications, such as genomic studies of multifactorial diseases, including immune system and inflammation‐related disorders, and donor selection in organ… read more here.
Keywords: hla alleles; accurate; hla typing; hla ... See more keywords
Association of HLA class I and II genes with Middle East respiratory syndrome coronavirus infection in Koreans
Sign Up to like & getrecommendations! Published in 2021 at "Immunity"
DOI: 10.1002/iid3.541
Abstract: Middle East Respiratory Syndrome (MERS) caused by MERS‐coronavirus (CoV) is a lower respiratory tract disease characterized by a high mortality rate. MERS‐CoV spread from Saudi Arabia to other countries, including South Korea. Dysfunction of the… read more here.
Keywords: hla; hla class; respiratory syndrome; association hla ... See more keywords
Association of end‐stage renal disease with HLA phenotypes and panel reactive antibodies in patients awaiting renal transplantation in Hunan Province
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24251
Abstract: To explore the immune‐related genetic susceptibility of human leukocyte antigen (HLA) alleles and their correlation with panel reactive antibody (PRA) generation during end‐stage renal disease (ESRD) progression. read more here.
Keywords: end stage; hla; renal disease; stage renal ... See more keywords
Genome-wide association study of 7661 Chinese Han individuals and fine-mapping major histocompatibility complex identifies HLA-DRB1 as associated with IgA vasculitis.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of clinical laboratory analysis"
DOI: 10.1002/jcla.24457
Abstract: BACKGROUND Immunoglobulin-A vasculitis (IgAV) is an immune-related systemic vasculitis with an unclear etiology. Genetic predisposition is now considered to be closely associated with the development of the disease, and it is essential to reveal the… read more here.
Keywords: drb1 hla; study; vasculitis; hla drb1 ... See more keywords