Efficacy of plasmapheresis and semi‐selective immunoadsorption for removal of anti‐HLA antibodies
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DOI: 10.1002/jca.21858
Abstract: In organ transplantation, apheresis is frequently used for removal of anti‐HLA antibodies. However, it is unclear whether plasmapheresis (PP) or semi‐selective immunoadsorption (IA) should be employed, and the optimal number of apheresis sessions required to… read more here.
Keywords: plasmapheresis semi; selective immunoadsorption; hla antibodies; semi selective ... See more keywords
Down syndrome with neonatal alloimmune thrombocytopenia due to anti-HLA A31 and B61 antibodies
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DOI: 10.1007/s12185-021-03092-z
Abstract: Neonatal alloimmune thrombocytopenia (NAIT) arises from fetomaternal platelet incompatibility that results in transplacental passage of maternal antibodies mostly against fetal human platelet antigens (HPA), whereas NAIT due to anti-human leukocyte antigen (HLA) antibodies is extremely… read more here.
Keywords: alloimmune thrombocytopenia; hla antibodies; hla; neonatal alloimmune ... See more keywords
Non HLA Antibodies in Serum Prior to the Onset of Chronic Lung Allograft Dysfunction
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DOI: 10.1016/j.healun.2021.01.465
Abstract: Purpose Non-human leukocyte antigen (HLA) antibodies have been associated with chronic lung allograft dysfunction (CLAD). Whether they predate CLAD is unclear. We hypothesized that patients destined to develop CLAD might develop non-HLA antibodies prior to… read more here.
Keywords: chronic lung; clad; non hla; hla antibodies ... See more keywords
OR6 Successful deceased donor kidney transplantation of highly sensitized candidates across positive cross match and strong donor-specific HLA-DP antibodies without desensitization
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DOI: 10.1016/j.humimm.2018.07.011
Abstract: Aim Over 50% of kidney transplant (Ktx) candidates with 100% CPRA display HLA-DP antibodies, which impair the chances of finding a compatible deceased donor (DD) despite national sharing. Herein, we assessed the impact of donor-specific… read more here.
Keywords: dsa; hla antibodies; highly sensitized; donor ... See more keywords
P114 Does HLA-DR matching prevent formation of de novo anti-donor HLA-DQ antibodies?
Sign Up to like & getrecommendations! Published in 2018 at "Human Immunology"
DOI: 10.1016/j.humimm.2018.07.172
Abstract: Aim Donor specific antibodies (DSA) directed to mismatched HLA-DQB antigens are the most prevalent DSA after transplantation. Such DSA have been implicated in the pathogenesis of chronic antibody mediated rejection and graft loss. Currently, patients… read more here.
Keywords: dsa; hla antibodies; hla; hla matching ... See more keywords
HLA antibodies are associated with deterioration of kidney allograft function irrespective of donor specificity.
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DOI: 10.1016/j.humimm.2020.10.010
Abstract: BACKGROUND Donor-specific antibodies are associated with high immunological risk and poor allograft outcome. Risk and clinical relevance of non-donor-specific HLA antibodies is less clear. METHODS A retrospective single-center study was conducted in all patients receiving… read more here.
Keywords: hla antibodies; allograft; donor; donor specificity ... See more keywords
HLA epitopes - Empirically defined as conformational amino acids sequences of the HLA antigen and are likely to be part of the binding sites of anti-HLA antibodies.
Sign Up to like & getrecommendations! Published in 2022 at "Human immunology"
DOI: 10.1016/j.humimm.2021.12.004
Abstract: Antibodies against HLA antigens are ubiquitous in the sera of transplant patients. Analysis of anti-HLA antibodies specificity has gone through a long history of development using assays like agglutination and lymphocytotoxicity, which utilize lymphocytes, and… read more here.
Keywords: anti hla; hla antibodies; hla antigens; hla epitopes ... See more keywords
The emerging field of non-HLA-antibodies in transplant medicine and beyond.
Sign Up to like & getrecommendations! Published in 2021 at "Kidney international"
DOI: 10.1016/j.kint.2021.04.044
Abstract: The major medical advances in our knowledge of the human leukocyte antigen (HLA) system have allowed to uncover several gaps in our understanding of alloimmunity. Although the non-HLA system has long sparked the interest of… read more here.
Keywords: medicine; emerging field; immunity; non hla ... See more keywords
Frequency of Human Leukocyte Antigens and Donor Specific Antibodies in Long-Term Living Donor Kidney Transplantation.
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DOI: 10.1016/j.transproceed.2019.01.195
Abstract: PURPOSE HLA antibodies have been shown to be associated with late graft loss. In this study, we defined the incidence and profiles of anti-HLA antibodies and their impact on graft outcome in long-term kidney recipients.… read more here.
Keywords: presence; class; hla antibodies; anti hla ... See more keywords
Chronic Active Antibody-Mediated Rejection With Donor-Specific Anti-HLA-DP Antibodies Following Living Donor Kidney Transplantation: A Case Report.
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DOI: 10.1016/j.transproceed.2020.02.130
Abstract: Posttransplant donor-specific anti-HLA antibodies (DSA) cause chronic antibody-mediated rejection. Anti-DR and anti-DQ DSAs have especially been shown to be associated with negative graft function. In contrast, the prevalence and significance of anti-DP DSA have not been… read more here.
Keywords: antibody mediated; mediated rejection; hla antibodies;
Antibody response to HBV vaccination on dialysis does not correlate with the development of deNovo anti-HLA antibodies after renal transplantation.
Sign Up to like & getrecommendations! Published in 2017 at "Transplant immunology"
DOI: 10.1016/j.trim.2017.04.003
Abstract: BACKGROUND Response to Hepatitis B virus (HBV) vaccination can be diminished in some (50-80%) but not all dialysis patients. We hypothesized, that the response to vaccination on dialysis may correlate with the development of anti-HLA… read more here.
Keywords: response; hbv vaccination; hla antibodies; anti hla ... See more keywords