Conserved HLA binding peptides from five non-structural proteins of SARS-CoV-2—An in silico glance
Sign Up to like & getrecommendations! Published in 2020 at "Human Immunology"
DOI: 10.1016/j.humimm.2020.08.001
Abstract: Abstract Coronavirus Disease 2019 (COVID-19) is a dangerous global threat that has no clinically approved treatment yet. Bioinformatics represent an outstanding approach to reveal key immunogenic regions in viral proteins. Here, five non-structural proteins (NSP)… read more here.
Keywords: binding peptides; five non; non structural; sars cov ... See more keywords
The antigenic variability of HCV in viral HLA-Ag binding is related to the activation of the host immune response
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-15605-0
Abstract: Our previous data show that hepatitis C virus (HCV) genotype 1 patients expressing the HLA-DQB1 * 0301 allele have a combined response probability of 69%, while the remaining 31% do not respond, probably because the HCV immunodominant… read more here.
Keywords: antigenic variability; viral hla; response; dqb1 0301 ... See more keywords
Neoantigens as potential vaccines in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-003978
Abstract: Background Neoantigens, new immunogenic sequences arising from tumor mutations, have been associated with response to immunotherapy and are considered potential targets for vaccination. Hepatocellular carcinoma (HCC) is a moderately mutated tumor, where the neoantigen repertoire… read more here.
Keywords: hepatocellular carcinoma; hla; neoantigens potential; potential vaccines ... See more keywords
Targeted Delivery of the HLA-B∗27-Binding Peptide into the Endoplasmic Reticulum Suppresses the IL-23/IL-17 Axis of Immune Cells in Spondylarthritis
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DOI: 10.1155/2017/4016802
Abstract: Ankylosing spondylitis (AS) is highly associated with the expression of human leukocyte antigen-B27 (HLA-B∗27). HLA-B∗27 heavy chain (B27-HC) has an intrinsic propensity to fold slowly, leading to the accumulation of the misfolded B27-HC in the… read more here.
Keywords: b27; endoplasmic reticulum; delivery hla; hla ... See more keywords
Peptidome Surveillance Across Evolving SARS-CoV-2 Lineages Reveals HLA Binding Conservation in Nucleocapsid Among Variants With Most Potential for T-Cell Epitope Loss in Spike
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.918928
Abstract: To provide a unique global view of the relative potential for evasion of CD8+ and CD4+ T cells by SARS-CoV-2 lineages as they evolve over time, we performed a comprehensive analysis of predicted HLA-I and… read more here.
Keywords: cell; loss; sars cov; hla binding ... See more keywords