P264 Impact of the HLA-DQ1*05 alelle on the initial response to infliximab in patients with Inflammatory Bowel Disease
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DOI: 10.1093/ecco-jcc/jjab076.390
Abstract: HLA-DQA1*05 Carriage is associated with development of anti-drug antibodies to infliximab in patients With Crohn’s Disease (Sazonovs et al. Gastroenterology 2019). Our group has shown that the presence of this allele is also an independent… read more here.
Keywords: hla dqa1; response infliximab; hla;
OP37 Effect of the HLA-DQA1*05 allele on the efficacy of ustekinumab in patients with Crohn's Disease. Multicenter study based on the ENEIDA registry of GETECCU
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DOI: 10.1093/ecco-jcc/jjad212.0037
Abstract: HLA-DQA1*05 carriage is associated with the development of anti-drug antibodies and loss of response (LOR) to tumour necrosis factor antagonists (anti-TNF) in patients with inflammatory bowel diseases (IBD)1. Ustekinumab has shown very low rates of… read more here.
Keywords: hla dqa1; hla; crohn disease; patients crohn ... See more keywords
P897 The association of HLA-DQA1*05 carriage with immunogenicity to anti-tumour necrosis factor therapy and drug persistence in Asian patients with inflammatory bowel disease
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DOI: 10.1093/ecco-jcc/jjad212.1027
Abstract: HLA-DQA1*05 carriage increases anti-tumour necrosis factor (TNF) immunogenicity and lowers drug persistence in European inflammatory bowel disease (IBD) patients. There is a paucity of data for Asian patients. We hypothesize that the HLA-DQA1*05 allele is… read more here.
Keywords: dqa1 carriage; persistence; anti tnf; hla dqa1 ... See more keywords
N31 HLA-DQA1*05 detection in saliva, an effective alternative in the monitoring and control of patients with Inflammatory Bowel Disease
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Crohn's and Colitis"
DOI: 10.1093/ecco-jcc/jjad212.1403
Abstract: The development of Inflammatory Bowel Disease (IBD) appears to be related to genetic susceptibility and an excessive immune response of the intestinal mucosa. Tumour necrosis factor (anti-TNF) therapies are the most widely used biologic drugs… read more here.
Keywords: detection; hla dqa1; dqa1; anti tnf ... See more keywords
High expression of HLA-DQA1 predicts poor outcome in patients with esophageal squamous cell carcinoma in Northern China
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DOI: 10.1097/md.0000000000014454
Abstract: Background: Our previous studies demonstrate that the major histocompatibility complex (MHC) is associated with the progression of esophageal squamous cell carcinoma (ESCC). HLA-DQA1, which belongs to the MHC Class II family, may be a potential… read more here.
Keywords: hla dqa1; high expression; escc; hla ... See more keywords
Does HLA‐DQA1*05 carriage have a greater impact on the outcome of infliximab therapy for isolated small‐bowel Crohn's disease?
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Immunogenetics"
DOI: 10.1111/iji.12696
Abstract: Carriage of HLA‐DQA1*05 is thought to increase the formation of anti‐tumour necrosis factor alpha (TNF‐α) antibodies, reducing the drug efficacy in Crohn's disease (CD) patients. However, little data are currently available for small‐bowel Crohn's disease… read more here.
Keywords: small bowel; hla dqa1; hla; crohn disease ... See more keywords
Characterization of the novel HLA‐DQA1*04:05 allele by sequencing‐based typing
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DOI: 10.1111/tan.13431
Abstract: HLA‐DQA1*04:05 differs from HLA‐DQA1*04:01:01:01 by one nucleotide substitution at codon 26 in exon 2. read more here.
Keywords: characterization novel; dqa1 allele; hla; novel hla ... See more keywords
Characterization of the novel HLA‐DQA1*01:27 allele by sequencing‐based typing
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DOI: 10.1111/tan.13647
Abstract: HLA‐DQA1*01:27 differs from HLA‐DQA1*01:01:01:01 by one nucleotide substitution in codon 221 in exon 4. read more here.
Keywords: characterization novel; dqa1 allele; hla; novel hla ... See more keywords
Characterization of the first HLA‐DQA1*01:05:01 variant, DQA1*01:05:01:02, found in a Brazilian individual
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DOI: 10.1111/tan.13673
Abstract: Characterization of the first HLA‐DQA1*01:05:01 variant, called HLA‐DQA1*01:05:01:02. read more here.
Keywords: dqa1; characterization first; dqa1 variant; first hla ... See more keywords
Characterization and confirmation of the HLA‐DQA1*04:01:01:09 allele, identified in a Brazilian individual
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DOI: 10.1111/tan.13738
Abstract: Characterization and confirmation of an HLA‐DQA1*04:01:01 variant, HLA‐DQA1*04:01:01:09. read more here.
Keywords: hla dqa1; confirmation hla; characterization confirmation; hla ... See more keywords
Characterization of the novel HLA‐DQA1*04:08 allele by sequencing‐based typing
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DOI: 10.1111/tan.13820
Abstract: HLA‐DQA1*04:08 differs from HLA‐DQA1*04:01:01:01 by one nucleotide substitution in codon 217 in exon 4. read more here.
Keywords: characterization novel; dqa1 allele; hla; novel hla ... See more keywords