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   Articles with "hla dr4" as a keyword



Characteristics of autoantibody-positive individuals without high-risk HLA-DR4-DQ8 or HLA-DR3-DQ2 haplotypes

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recommendations! Published in 2024 at "Diabetologia"

DOI: 10.1007/s00125-024-06338-7

Abstract: Many studies of type 1 diabetes pathogenesis focus on individuals with high-risk HLA haplotypes. We tested the hypothesis that, among islet autoantibody-positive individuals, lacking HLA-DRB1*04-DQA1*03-DQB1*0302 (HLA-DR4-DQ8) and/or HLA-DRB1*0301-DQA1*0501-DQB1*0201 (HLA-DR3-DQ2) is associated with phenotypic differences, compared… read more here.

Keywords: hla dr4; dr3; dr4 dq8; group ... See more keywords

Rheumatoid Factor Recognizes Specific Domains of the IgG Heavy Chain Complexed with HLA Class II Molecules.

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recommendations! Published in 2023 at "Rheumatology"

DOI: 10.1093/rheumatology/kead024

Abstract: OBJECTIVE We previously reported that rheumatoid factor (RF) recognized the IgG heavy chain (IgGH)/RA-susceptible HLA class II molecule complex. In the present study, we investigated the molecular mechanisms underlying HLA binding to and the RF… read more here.

Keywords: hla dr4; hla class; ch1 ch2; ch1 ... See more keywords

Accumulation of HLA-DR4 in Colonic Epithelial Cells Causes Severe Colitis in Homozygous HLA-DR4 Transgenic Mice

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recommendations! Published in 2017 at "Inflammatory Bowel Diseases"

DOI: 10.1097/mib.0000000000001282

Abstract: Background: Homozygous HLA-DR4/I-Ed transgenic mice (tgm) spontaneously developed colitis similar to human ulcerative colitis. We explored whether endoplasmic reticulum stress in colonic epithelial cells due to overexpression of HLA-DR4/I-Ed was involved in the pathogenesis of… read more here.

Keywords: epithelial cells; dr4; colonic epithelial; hla dr4 ... See more keywords

Generation of TGFβR2(-1) neoantigen-specific HLA-DR4-restricted T cell receptors for cancer therapy

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recommendations! Published in 2023 at "Journal for Immunotherapy of Cancer"

DOI: 10.1136/jitc-2022-006001

Abstract: Background Adoptive transfer of patient’s T cells, engineered to express a T cell receptor (TCR) with defined novel antigen specificity, is a convenient form of cancer therapy. In most cases, major histocompatibility complex (MHC) I-restricted… read more here.

Keywords: hla dr4; cell; tgf; cancer ... See more keywords

Evaluation of Salivary HLA-DR4 and MMP-8 Levels Along with Porphyromonas gingivalis in Periodontitis Patients with Rheumatoid Arthritis

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recommendations! Published in 2025 at "F1000Research"

DOI: 10.12688/f1000research.164552.1

Abstract: Background Periodontitis (PD) is a chronic infectious inflammatory disease that affects the tissues supporting teeth and results in a progressive deterioration of the alveolar bone. Rheumatoid arthritis (RA), a systemic autoimmune disease that has been… read more here.

Keywords: hla dr4; rheumatoid arthritis; periodontitis patients; dr4 ... See more keywords