Rheumatoid Factor Recognizes Specific Domains of the IgG Heavy Chain Complexed with HLA Class II Molecules.
Sign Up to like & getrecommendations! Published in 2023 at "Rheumatology"
DOI: 10.1093/rheumatology/kead024
Abstract: OBJECTIVE We previously reported that rheumatoid factor (RF) recognized the IgG heavy chain (IgGH)/RA-susceptible HLA class II molecule complex. In the present study, we investigated the molecular mechanisms underlying HLA binding to and the RF… read more here.
Keywords: hla dr4; hla class; ch1 ch2; ch1 ... See more keywords
Accumulation of HLA-DR4 in Colonic Epithelial Cells Causes Severe Colitis in Homozygous HLA-DR4 Transgenic Mice
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DOI: 10.1097/mib.0000000000001282
Abstract: Background: Homozygous HLA-DR4/I-Ed transgenic mice (tgm) spontaneously developed colitis similar to human ulcerative colitis. We explored whether endoplasmic reticulum stress in colonic epithelial cells due to overexpression of HLA-DR4/I-Ed was involved in the pathogenesis of… read more here.
Keywords: epithelial cells; dr4; colonic epithelial; hla dr4 ... See more keywords
Generation of TGFβR2(-1) neoantigen-specific HLA-DR4-restricted T cell receptors for cancer therapy
Sign Up to like & getrecommendations! Published in 2023 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-006001
Abstract: Background Adoptive transfer of patient’s T cells, engineered to express a T cell receptor (TCR) with defined novel antigen specificity, is a convenient form of cancer therapy. In most cases, major histocompatibility complex (MHC) I-restricted… read more here.
Keywords: hla dr4; cell; tgf; cancer ... See more keywords