HLA‐DRB1*15:01 is a co‐receptor for Epstein–Barr virus, linking genetic and environmental risk factors for multiple sclerosis
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Immunology"
DOI: 10.1002/eji.202149179
Abstract: Figure 1. Synopsis of the experimental strategy. The CD21-positive, human leukocyte antigen (HLA) class II-negative lymphoblastoid cell line 721.174 was co-transfected with plasmids encoding the HLA-DR α-chain HLA-DRA*01:01 and the HLA-DR β-chain HLA-DRB1*01:01 or HLADRB1*15:01.… read more here.
Keywords: epstein barr; hla drb1; hla; drb1 receptor ... See more keywords
Genome-wide association study of 7661 Chinese Han individuals and fine-mapping major histocompatibility complex identifies HLA-DRB1 as associated with IgA vasculitis.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of clinical laboratory analysis"
DOI: 10.1002/jcla.24457
Abstract: BACKGROUND Immunoglobulin-A vasculitis (IgAV) is an immune-related systemic vasculitis with an unclear etiology. Genetic predisposition is now considered to be closely associated with the development of the disease, and it is essential to reveal the… read more here.
Keywords: drb1 hla; study; vasculitis; hla drb1 ... See more keywords
Haplotype‐dependent HLA‐DRB1‐DQB1 susceptibility to occult HBV infection in Xi'an Han population
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.2102
Abstract: Occult hepatitis B virus (HBV) infection (OBI) is primarily characterized by the persistence of HBV‐DNA in the liver tissues and/or in the serum without detectable HBsAg. Human leukocyte antigen (HLA) polymorphisms have been found to… read more here.
Keywords: hbv infection; drb1 dqb1; hla drb1; hla ... See more keywords
Frequency of human leukocyte antigens class II-DR alleles (HLA-DRB1) in Argentinian patients with early arthritis
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Rheumatology"
DOI: 10.1007/s10067-018-4319-4
Abstract: Patients with rheumatoid arthritis (RA) or undifferentiated arthritis (UA) in the CONAART database (Argentine Consortium for Early Arthritis) were assessed for genetic risk factors for RA, specifically for HLA-DRB1 alleles and the PTPN22 rs2476601 polymorphism… read more here.
Keywords: frequency; hla drb1; drb1; early arthritis ... See more keywords
HLA-DRB1 the notorious gene in the mosaic of autoimmunity
Sign Up to like & getrecommendations! Published in 2017 at "Immunologic Research"
DOI: 10.1007/s12026-016-8817-7
Abstract: The major histocompatibility complex system is the most polymorphic gene cluster of the mammal genome. In humans, this is a genomic locus known as the human leukocyte antigen (HLA) system. The HLA encodes mostly immune-associated… read more here.
Keywords: hla drb1; hla; drb1 notorious; gene mosaic ... See more keywords
Association between Entamoeba histolytica infection and human leukocyte antigen HLA- DRB1
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Medicine and Surgery"
DOI: 10.1016/j.amsu.2018.10.019
Abstract: Background Entamoeba histolytica is the parasitic amoeba which caused amebiasis in human and responsible of 100,000 deaths every year. There is currently no vaccine against this parasite. The innate and adaptive immunity are important in… read more here.
Keywords: entamoeba histolytica; hla drb1; histolytica infection;
Interaction of HLA-DRB1* alleles and CTLA4 (+49 AG) gene polymorphism in Autoimmune Thyroid Disease.
Sign Up to like & getrecommendations! Published in 2018 at "Gene"
DOI: 10.1016/j.gene.2017.11.057
Abstract: Autoimmune Thyroid Diseases (AITDs), including Hashimoto's thyroiditis (HT) and Graves' disease (GD), arise by the complex interaction of genes and environmental factors. The aim of present study was to study the susceptible associations of HLA-DRB1*… read more here.
Keywords: hla drb1; drb1; autoimmune thyroid; drb1 alleles ... See more keywords
Human Leukocyte Antigen class II polymorphisms among Croatian patients with type 1 diabetes and autoimmune polyglandular syndrome type 3 variant.
Sign Up to like & getrecommendations! Published in 2018 at "Gene"
DOI: 10.1016/j.gene.2018.06.083
Abstract: This study included 161 patients: 92 patients had type 1 diabetes (T1D) while 69 patients had a combination of T1D and autoimmune thyroiditis, the so-called autoimmune polyglandular syndrome type 3 variant (APS3v). Those patients, as… read more here.
Keywords: drb1 drb1; hla drb1; drb1; dqb1 ... See more keywords
HLA-A, B, DRB1, DQA1, DQB1 alleles and haplotype frequencies in Dene and Cree cohorts in Manitoba, Canada.
Sign Up to like & getrecommendations! Published in 2017 at "Human immunology"
DOI: 10.1016/j.humimm.2017.03.009
Abstract: BACKGROUND First Nations in the Canadian province of Manitoba have disproportionately high rates of epidemic and endemic TB. Gene polymorphisms that modulate HLA Class I and II antigens are among the risk markers for TB,… read more here.
Keywords: drb1 dqa1; dene cree; hla drb1; hla ... See more keywords
P273 An NGSGO whole gene amplification strategy for the HLA-DRB1 gene
Sign Up to like & getrecommendations! Published in 2017 at "Human Immunology"
DOI: 10.1016/j.humimm.2017.06.333
Abstract: Aim High-resolution typing results are required to perform stem cell transplantations. This means that for both alleles at least the DNA sequence of core regions exon 2 and 3 for class I loci and exon… read more here.
Keywords: resolution; hla drb1; hla; whole gene ... See more keywords
P162 Progress towards gene editing of HLA-DRB1∗04:01 by CRISPR/Cas9
Sign Up to like & getrecommendations! Published in 2018 at "Human Immunology"
DOI: 10.1016/j.humimm.2018.07.219
Abstract: Aim The HLA-DRB1 locus represents the greatest genetic risk factor for susceptibility for rheumatoid arthritis (RA). We have refined this genetic association to a single amino acid polymorphism at position 71 that is associated with… read more here.
Keywords: crispr cas9; gene; hla drb1; drb1 ... See more keywords