NONINVASIVE GENOTYPING OF DONOR’S HLA IN KIDNEY TRANSPLANT PATIENTS BY TARGET CAPTURE SEQUENCING
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DOI: 10.1097/01.tp.0000698892.42421.2f
Abstract: Background: Antibody-mediated rejection (ABMR) is the major cause of kidney transplant failure, which requires donor-specific antibodies (DSA) for a definitive diagnosis based on Banff 2013. However, lack information about donor’s HLA genotypes is often encountered… read more here.
Keywords: donor hla; kidney transplant; hla genotypes; hla ... See more keywords
Associations of HLA genotypes with antithyroid drug-induced agranulocytosis: a systematic review and meta-analysis of pharmacogenomics studies.
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DOI: 10.1111/bcp.13989
Abstract: AIM Antithyroid drug (ATD)-induced agranulocytosis is a life-threatening adverse drug reaction. Previous studies suggested HLA genotypes may play an important role in ATD-induced agranulocytosis. To examine the associations between HLA genotypes and ATD-induced agranulocytosis, we… read more here.
Keywords: hla genotypes; atd induced; hla hla; induced agranulocytosis ... See more keywords
Impact of germline HLA genotypes on clinical outcomes in patients with urothelial cancer treated with pembrolizumab
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DOI: 10.1111/cas.15488
Abstract: Human leukocyte antigen class I (HLA‐I) genotypes are suggested to influence the cancer response to checkpoint blockade immunotherapy. This study assessed the impact of germline HLA genotypes on clinical outcomes in patients with chemoresistant advanced… read more here.
Keywords: outcomes patients; hla; treated pembrolizumab; hla genotypes ... See more keywords
Host KIR/HLA-C Genotypes Determine HIV-Mediated Changes of the NK Cell Repertoire and Are Associated With Vpu Sequence Variations Impacting Downmodulation of HLA-C
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DOI: 10.3389/fimmu.2022.922252
Abstract: NK cells play a pivotal role in viral immunity, utilizing a large array of activating and inhibitory receptors to identify and eliminate virus-infected cells. Killer-cell immunoglobulin-like receptors (KIRs) represent a highly polymorphic receptor family, regulating… read more here.
Keywords: hiv; hla; hla genotypes; kir hla ... See more keywords
Prediction of HLA genotypes from single-cell transcriptome data
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DOI: 10.3389/fimmu.2023.1146826
Abstract: The human leukocyte antigen (HLA) locus plays a central role in adaptive immune function and has significant clinical implications for tissue transplant compatibility and allelic disease associations. Studies using bulk-cell RNA sequencing have demonstrated that… read more here.
Keywords: cell; hla; accuracy; hla genotypes ... See more keywords