OTU-022 Gwas of microscopic colitis in the UK biobank confirms association within the HLA region
Sign Up to like & getrecommendations! Published in 2018 at "Gut"
DOI: 10.1136/gutjnl-2018-bsgabstracts.362
Abstract: Introduction The pathogenesis of microscopic colitis is poorly elucidated: it reportedly involves immune responses to luminal factors in genetically predisposed individuals. Previous genetic studies reported associations with HLA risk alleles in collagenous but not lymphocytic… read more here.
Keywords: hla region; association; colitis; within hla ... See more keywords
Longitudinal Pattern of First-Phase Insulin Response Is Associated With Genetic Variants Outside the Class II HLA Region in Children With Multiple Autoantibodies
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DOI: 10.2337/db19-0329
Abstract: A declining first-phase insulin response (FPIR) is associated with positivity for multiple islet autoantibodies, irrespective of class II HLA DR-DQ genotype. We examined the associations of FPIR with genetic variants outside the HLA DR-DQ region… read more here.
Keywords: class; genetic variants; hla region; multiple autoantibodies ... See more keywords
Type 1 Diabetes and the HLA Region: Genetic Association Besides Classical HLA Class II Genes
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DOI: 10.3389/fgene.2021.683946
Abstract: Type 1 diabetes is an autoimmune disease with rising incidence in high-income countries. Genetic and environmental predisposing factors contribute to the etiology of the disease, although their interaction is not sufficiently understood to allow for… read more here.
Keywords: etiology; hla region; classical hla; association ... See more keywords