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   Articles with "hlcs" as a keyword



Clinical, biochemical, and genetic analysis of a Chinese Han pedigree with holocarboxylase synthetase deficiency: a case report

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recommendations! Published in 2020 at "BMC Medical Genetics"

DOI: 10.1186/s12881-020-01080-4

Abstract: Background Holocarboxylase synthetase (HLCS) deficiency is a rare inborn disorder of biotin metabolism, which results in defects in several biotin-dependent carboxylases and presents with metabolic ketoacidosis and skin lesions. Case presentation In this paper, we… read more here.

Keywords: hlcs; chinese han; holocarboxylase synthetase; gene ... See more keywords

The predictive function of miR-122-5p and its action mechanism by regulating PKM2 in metabolic syndrome

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recommendations! Published in 2025 at "BMC Endocrine Disorders"

DOI: 10.1186/s12902-025-01888-2

Abstract: Obesity will cause metabolic syndrome (Mets) easily, and its pathogenesis is not completely clear. To probe into the predictive value of miR-122-5p and its regulatory mechanism in Mets. The predictive effect of miR-122-5p on Mets… read more here.

Keywords: hlcs; pkm2; mir 122; regulating pkm2 ... See more keywords

Development of a method of passaging and freezing human iPS cell-derived hepatocytes to improve their functions

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recommendations! Published in 2023 at "PLOS ONE"

DOI: 10.1371/journal.pone.0285783

Abstract: Human induced pluripotent stem (iPS) cell-derived hepatocyte-like cells (HLCs) are expected to replace primary human hepatocytes as a new source of functional hepatocytes in various medical applications. However, the hepatic functions of HLCs are still… read more here.

Keywords: ips cell; human ips; hlcs; method passaging ... See more keywords

HiPSC-Derived Hepatocyte-like Cells Can Be Used as a Model for Transcriptomics-Based Study of Chemical Toxicity.

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recommendations! Published in 2021 at "Toxics"

DOI: 10.3390/toxics10010001

Abstract: Traditional toxicity risk assessment approaches have until recently focussed mainly on histochemical readouts for cell death. Modern toxicology methods attempt to deduce a mechanistic understanding of pathways involved in the development of toxicity, by using… read more here.

Keywords: hipsc derived; like cells; toxicity; hlcs ... See more keywords

Mechanism of holocarboxylase synthetase and biotin supplementation in promoting adipose development

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recommendations! Published in 2025 at "Journal of Animal Science and Technology"

DOI: 10.5187/jast.2025.e44

Abstract: 8 Pig back fat (BF) thickness is a key indicator for evaluating lipid deposition in pigs. Consuming pork belly with 9 thick BF can increase cholesterol intake and negatively impact human health. Holocarboxylase synthetase (HLCS)… read more here.

Keywords: biotin; development; hlcs; holocarboxylase synthetase ... See more keywords