Design and Synthesis of New Pyrimidine-Quinolone Hybrids as Novel hLDHA Inhibitors
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DOI: 10.3390/ph15070792
Abstract: A battery of novel pyrimidine-quinolone hybrids was designed by docking scaffold replacement as lactate dehydrogenase A (hLDHA) inhibitors. Structures with different linkers between the pyrimidine and quinolone scaffolds (10-21 and 24–31) were studied in silico,… read more here.
Keywords: hldha inhibitors; new pyrimidine; quinolone; quinolone hybrids ... See more keywords