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   Articles with "hle cells" as a keyword



Circular RNA circZNF292 regulates H2O2‐induced injury in human lens epithelial HLE‐B3 cells depending on the regulation of the miR‐222‐3p/E2F3 axis

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recommendations! Published in 2021 at "Cell Biology International"

DOI: 10.1002/cbin.11615

Abstract: Circular RNAs (circRNAs) play important roles in the pathogenesis of age‐related cataract (ARC). CircRNA zinc finger protein 292 (circZNF292, hsa_circ_0004058) is downregulated in ARC lens capsules. Here, we focused on its precise roles in oxidative… read more here.

Keywords: mir 222; h2o2 induced; hle cells; cell ... See more keywords

Nitro Dihydrocapsaicin, a Non-Pungent Capsaicin Analogue, Inhibits Cellular Senescence of Lens Epithelial Cells via Upregulation of SIRT1

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recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms232213960

Abstract: Diabetic cataracts are a common complication that can cause blindness among patients with diabetes mellitus. A novel nitro dihydrocapsaicin (NDHC), a capsaicin analog, was constructed to have a non-pungency effect. The objective of this research… read more here.

Keywords: lens epithelial; hle cells; senescence; cellular senescence ... See more keywords

Selenium Nanoparticles: Synthesis, Stability and In Vitro Evaluation in Human Lens Epithelial Cells

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recommendations! Published in 2025 at "Pharmaceutics"

DOI: 10.3390/pharmaceutics17091157

Abstract: Background/Objectives: Oxidative stress plays a critical role in the development of ocular diseases such as cataracts. Selenium nanoparticles (SeNPs) offer antioxidant benefits with low toxicity. This study aimed to evaluate the antioxidant activity of SeNPs… read more here.

Keywords: hle cells; human lens; lens epithelial; nanoparticles synthesis ... See more keywords

Electric field exposure promotes epithelial-mesenchymal transition in human lens epithelial cells via integrin β1-FAK signaling

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recommendations! Published in 2017 at "Molecular Medicine Reports"

DOI: 10.3892/mmr.2017.7086

Abstract: Electric field (EF) exposure can affect the elongation, migration, orientation, and division of cells. The present study tested the hypothesis that EF may also affect epithelial-mesenchymal transition (EMT) in lens epithelial cells and that this… read more here.

Keywords: integrin fak; lens epithelial; exposure; hle cells ... See more keywords

Down-regulation of NRIP1 alleviates pyroptosis in human lens epithelial cells exposed to hydrogen peroxide by inhibiting NF-κB activation

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recommendations! Published in 2022 at "Tropical Journal of Pharmaceutical Research"

DOI: 10.4314/tjpr.v22i2.6

Abstract: Purpose: To investigate the role of nuclear receptor-interacting protein 1 (NRIP1) in oxidative stressinduced apoptosis and pyroptosis in cataract disease.Methods: Human lens epithelial cells (HLE-B3 cells) were exposed to hydrogen peroxide (H2O2). NRIP1 expression in… read more here.

Keywords: hydrogen peroxide; human lens; lens epithelial; h2o2 ... See more keywords