DNA Sequence Specificity Reveals a Role of the HLTF HIRAN Domain in the Recognition of Trinucleotide Repeats.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00027
Abstract: DNA damage tolerance (DDT) pathways enable cells to cope with a variety of replication blocks that threaten their ability to complete DNA replication. Helicase-like transcription factor (HLTF) plays a central role in the error-free DDT… read more here.
Keywords: hltf; dna; hiran domain; hltf hiran ... See more keywords
Degradation of helicase-like transcription factor (HLTF) by β-TrCP promotes hepatocarcinogenesis via activation of the p62/mTOR axis.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of molecular cell biology"
DOI: 10.1093/jmcb/mjad012
Abstract: Helicase-like transcription factor (HLTF) has been found to be involved in the maintenance of genome stability and tumour suppression, but whether its downregulation in cancers is associated with posttranslational regulation remains unclear. Here, we observed… read more here.
Keywords: trcp; hcc; hltf; p62 mtor ... See more keywords
Regulation of HLTF-mediated PCNA polyubiquitination by RFC and PCNA monoubiquitination levels determines choice of damage tolerance pathway
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DOI: 10.1093/nar/gky943
Abstract: Abstract DNA-damage tolerance protects cells via at least two sub-pathways regulated by proliferating cell nuclear antigen (PCNA) ubiquitination in eukaryotes: translesion DNA synthesis (TLS) and template switching (TS), which are stimulated by mono- and polyubiquitination,… read more here.
Keywords: hltf; damage tolerance; polyubiquitination; choice ... See more keywords
Helicase-like transcription factor expression is associated with a poor prognosis in Non-Small-Cell Lung Cancer (NSCLC)
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DOI: 10.1186/s12885-018-4215-y
Abstract: BackgroundThe relapse rate in early stage non-small cell lung cancer (NSCLC) after surgical resection is high. Prognostic biomarkers may help identify patients who may benefit from additional therapy. The Helicase-like Transcription Factor (HLTF) is a… read more here.
Keywords: hltf; cell; expression; lung cancer ... See more keywords
HLTF suppresses the migration and invasion of colorectal cancer cells via TGF‑β/SMAD signaling in vitro.
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DOI: 10.3892/ijo.2018.4591
Abstract: Helicase‑like transcription factor (HLTF) has been identified as a tumor suppressor gene. The hypermethylation of HTLF is frequently observed in various types of cancer, including colorectal cancer (CRC). However, the mechanisms through which HLTF suppresses CRC… read more here.
Keywords: crc cells; hltf; tgf smad; expression ... See more keywords