Abstract 1625: A novel SOS1 inhibitor, HM99462 demonstrates antitumor activity against KRAS-mutant cancers
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DOI: 10.1158/1538-7445.am2023-1625
Abstract: KRAS is a well-known oncogene with the highest mutation rate among various cancers. KRAS cycles between GDP-loaded ‘off’ and GTP-loaded ‘on’ states induce downstream signal transduction to promote cell proliferation and survival. Interconversion between ‘on’… read more here.
Keywords: sos1; hm99462; activity; novel sos1 ... See more keywords