Identification of 7,8‐dihydroxy‐3‐phenylcoumarin as a reversible monoamine oxidase enzyme inhibitor
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22651
Abstract: We herein report the biological evaluation of 3‐arylcoumarin derivatives (3a‐l) as potential human monoamine oxidase‐A and ‐B (hMAO‐A and hMAO‐B) inhibitors. The result indicated that 7,8‐dihydroxy‐3‐(4‐nitrophenyl)coumarin (3j) was most effective against MAO‐A (inhibition concentration [IC50] = 6.46 ± 0.02 µM)… read more here.
Keywords: hmao enzymes; hmao; identification dihydroxy; monoamine oxidase ... See more keywords
Rhamnocitrin isolated from Prunus padus var. seoulensis: A potent and selective reversible inhibitor of human monoamine oxidase A.
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DOI: 10.1016/j.bioorg.2018.10.051
Abstract: Three flavanones and two flavones were isolated from the leaves of Prunus padus var. seoulensis by the activity-guided screening for new monoamine oxidase (MAO) inhibitors. Among the compounds isolated, rhamnocitrin (5) was found to potently… read more here.
Keywords: padus var; monoamine oxidase; hmao hmao; var seoulensis ... See more keywords
Potent and selective inhibition of human monoamine oxidase-B by 4-dimethylaminochalcone and selected chalcone derivatives.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.06.167
Abstract: Six synthetic (1-6) and six natural (7-12) chalcones were tested for human monoamine oxidases (hMAOs) and acetylcholinesterase (AChE) inhibitory activities. Compounds 4-dimethylaminochalcone (2), 4'-chloro-4-dimethylaminochalcone (5), and 2,4'-dichloro-4-dimethylaminochalcone (1) potently inhibited hMAO-B with IC50 values of… read more here.
Keywords: inhibited hmao; human monoamine; dimethylaminochalcone; ic50 ... See more keywords