Analysis of DNA Hydroxymethylation Using Colorimetric Assay.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4899-7708-3_8
Abstract: Hydroxymethylcytosine (hmC or 5-hmC) is a nitrogen base occurring as a result of cytosine methylation followed by replacing a methyl group with a hydroxyl group through active oxidation. 5-hmC is considered to be one of… read more here.
Keywords: analysis dna; hydroxymethylation using; dna; using colorimetric ... See more keywords
Cross-sectional and longitudinal associations between global DNA (hydroxy) methylation and exposure biomarkers of the Hebei Spirit oil spill cohort in Taean, Korea.
Sign Up to like & getrecommendations! Published in 2020 at "Environmental pollution"
DOI: 10.1016/j.envpol.2020.114607
Abstract: The Hebei Spirit oil spill (HSOS) occurred on the west coast of South Korea (Taean county) on December 7, 2007, and studies revealed that exposure to the oil spill was associated with various adverse health… read more here.
Keywords: cross sectional; oil spill; exposure; global dna ... See more keywords
Nanoparticle-induced assembly of hydrophobically modified chitosan
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Simulation"
DOI: 10.1080/08927022.2017.1290235
Abstract: Abstract Hydrophobically modified chitosan (HMC) self-assembles in solution to form gels, making it suitable for applications in oil dispersion, hydrogel design and wound dressing. The self-assembly of HMC is driven by the association of hydrophobic… read more here.
Keywords: hydrophobically modified; network; density; modified chitosan ... See more keywords
Task Parallelism-Aware Deep Neural Network Scheduling on Multiple Hybrid Memory Cube-Based Processing-in-Memory
Sign Up to like & getrecommendations! Published in 2021 at "IEEE Access"
DOI: 10.1109/access.2021.3077294
Abstract: Processing-in-memory (PIM) comprises computational logic in the memory domain. It is the most promising solution to alleviate the memory bandwidth problem in deep neural network (DNN) processing. The hybrid memory cube (HMC), a 3D stacked… read more here.
Keywords: dnn; parallelism; memory; task ... See more keywords
An investigation of feeding high-moisture corn grain with slow-release urea supplementation on lactational performance, energy partitioning, and ruminal fermentation of dairy cows
Sign Up to like & getrecommendations! Published in 2017 at "Canadian Journal of Animal Science"
DOI: 10.1139/cjas-2016-0220
Abstract: Abstract: The objective of this experiment was to determine if lactational performance and energy partitioning by dairy cows would differ in response to dietary corn grain (CG) types [steam-flaked corn (SFC) vs. high-moisture corn (HMC)]… read more here.
Keywords: supplementation; energy; corn; hmc ... See more keywords
iRNA5hmC-HOC: High-order correlation information for identifying RNA 5-hydroxymethylcytosine modification
Sign Up to like & getrecommendations! Published in 2022 at "Journal of bioinformatics and computational biology"
DOI: 10.1142/s0219720022500172
Abstract: RNA 5-hydroxymethylcytosine (5 hmC) is an important RNA modification, which plays vital role in several biological processes. Currently, it is a hot topic to identify 5[Formula: see text]hmC sites due to its benefit in understanding… read more here.
Keywords: modification; hmc; high order; correlation information ... See more keywords
The CDK4/6 Inhibitor Palbociclib Exerts Growth-Inhibitory Effects on Neoplastic Mast Cells and Synergizes with Midostaurin in Producing Growth Arrest
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-116525
Abstract: Aggressive systemic mastocytosis (ASM) and mast cell leukemia (MCL) are rare, malignant diseases with an unfavorable prognosis. In a majority of patients, the transforming KIT mutation D816V is detectable. Currently, several drugs are available for… read more here.
Keywords: cell; cdk4; drug; cdk4 inhibitors ... See more keywords
Longitudinal Effects of Developmental Bisphenol A Exposure on Epigenome-Wide DNA Hydroxymethylation at Imprinted Loci in Mouse Blood
Sign Up to like & getrecommendations! Published in 2018 at "Environmental Health Perspectives"
DOI: 10.1289/ehp3441
Abstract: Background: Epigenetic machinery plays an important role in genomic imprinting, a developmental process that establishes parent-of-origin–specific monoallelic gene expression. Although a number of studies have investigated the role of 5-methylcytosine in imprinting control, the contribution… read more here.
Keywords: mouse blood; exposure; bpa exposure; hmc ... See more keywords
Decreased 5-hydroxymethylcytosine levels correlate with cancer progression and poor survival: a systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.13719
Abstract: Ten-eleven translocation (TET) enzymes catalyze the oxidation of 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC) and then to 5-formylcytosine (5-fC) and 5-carboxylcytosine (5-caC), resulting in genomic DNA demethylation. Decreased 5-hmC levels have been reported in a variety… read more here.
Keywords: systematic review; hmc levels; poor survival; hmc ... See more keywords
CRISPR/Cas9-engineering of HMC-1.2 cells renders a human mast cell line with a single D816V-KIT mutation: An improved preclinical model for research on mastocytosis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1078958
Abstract: The HMC-1.2 human mast cell (huMC) line is often employed in the study of attributes of neoplastic huMCs as found in patients with mastocytosis and their sensitivity to interventional drugs in vitro and in vivo.… read more here.
Keywords: cell; mastocytosis; d816v kit; hmc cells ... See more keywords
Induction of Apoptosis and Autophagy in Breast Cancer Cells by a Novel HDAC8 Inhibitor
Sign Up to like & getrecommendations! Published in 2019 at "Biomolecules"
DOI: 10.3390/biom9120824
Abstract: Epigenetic therapy has been demonstrated to be a viable strategy for breast cancer treatment. In this study, we report the anti-tumor activity of a hydroxamate-based histone deacetylase (HDAC)8-selective inhibitor, HMC, in breast cancer cells. MTT… read more here.
Keywords: breast; apoptosis; breast cancer; hmc ... See more keywords