Bioconversion of lovastatin to simvastatin by Streptomyces carpaticus toward the inhibition of HMG-CoA activity.
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and applied biochemistry"
DOI: 10.1002/bab.2429
Abstract: The aim of this study was the modification of lovastatin by microbes to improve its potential. Actinobacteria exhibit staggering diversity in terms of their biosynthetic capability for specialized metabolites which has been traced back to… read more here.
Keywords: hmg coa; analysis; simvastatin; lovastatin ... See more keywords
Isolation of HMG-CoA reductase inhibitors from aronia juice
Sign Up to like & getrecommendations! Published in 2020 at "Food bioscience"
DOI: 10.1016/j.fbio.2020.100535
Abstract: Abstract Daily ingestion of aronia juice is known to reduce serum low density lipoprotein cholesterol levels. However, the mechanism is not clear. In this study, the effect of aronia juice on the activity of human… read more here.
Keywords: reductase; hmg coa; juice; coa reductase ... See more keywords
In vitro and in silico studies of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitory activity of the cowpea Gln-Asp-Phe peptide.
Sign Up to like & getrecommendations! Published in 2018 at "Food chemistry"
DOI: 10.1016/j.foodchem.2018.03.132
Abstract: Previous studies have shown that cowpea protein positively interferes with cholesterol metabolism. In this study, we evaluated the ability of the fraction containing peptides of read more here.
Keywords: peptide; reductase; hmg coa; activity ... See more keywords
Applying asymptotic methods to synthetic biology: Modelling the reaction kinetics of the mevalonate pathway
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Theoretical Biology"
DOI: 10.1016/j.jtbi.2017.11.022
Abstract: Highlights • We investigate a kinetic model for the mevalonate pathway which includes inhibition effects and a sink of acetyl-CoA.• Of the enzymes in the pathway, upregulating HMG-CoA reductase has the most significant positive effect… read more here.
Keywords: applying asymptotic; hmg coa; mevalonate pathway; biology ... See more keywords
Acetaldehyde Dehydrogenase 2 regulates HMG-CoA reductase stability and cholesterol synthesis in the liver
Sign Up to like & getrecommendations! Published in 2021 at "Redox Biology"
DOI: 10.1016/j.redox.2021.101919
Abstract: HMG-CoA reductase (HMGCR) is the rate-limiting enzyme in cholesterol biosynthesis and the target for cholesterol-lowering therapy. Acetaldehyde dehydrogenase 2 (ALDH2) is primarily responsible for detoxifying ethanol-derived acetaldehyde and endogenous lipid aldehydes derived from lipid peroxidation.… read more here.
Keywords: acetaldehyde dehydrogenase; hmg coa; cholesterol synthesis; cholesterol ... See more keywords
Structural Modification of Natural Product Ganomycin I Leading to Discovery of a α-Glucosidase and HMG-CoA Reductase Dual Inhibitor Improving Obesity and Metabolic Dysfunction in Vivo.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b00107
Abstract: It is a great challenge to develop drugs for treatment of metabolic syndrome. With ganomycin I as a leading compound, 14 meroterpene derivatives were synthesized and screened for their α-glucosidase and HMG-CoA reductase inhibitory activities.… read more here.
Keywords: coa reductase; glucosidase hmg; hmg coa;
Model Lipid Raft Membranes for Embedding Integral Membrane Proteins: Reconstitution of HMG-CoA Reductase and Its Inhibition by Statins
Sign Up to like & getrecommendations! Published in 2022 at "Langmuir"
DOI: 10.1021/acs.langmuir.2c02115
Abstract: For the first time, HMG-CoA reductase, the membrane protein responsible for cholesterol synthesis, was incorporated into a lipid membrane consisting of DOPC:Chol:SM at a 1:1:1 molar ratio, which mimics the lipid rafts of cell membranes.… read more here.
Keywords: coa reductase; lipid raft; hmg coa; membrane ... See more keywords
HMG-CoA Reductase Inhibitors as Drug Leads against Naegleria fowleri.
Sign Up to like & getrecommendations! Published in 2020 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.0c00428
Abstract: Primary amebic meningoencephalitis (PAM), caused by the free-living ameba Naegleria fowleri, has a fatality rate of over 97%. Treatment of PAM relies on amphotericin B in combination with other drugs, but few patients have survived… read more here.
Keywords: hmg coa; fowleri; naegleria fowleri; drug ... See more keywords
High-throughput mapping of CoA metabolites by SAMDI-MS to optimize the cell-free biosynthesis of HMG-CoA
Sign Up to like & getrecommendations! Published in 2019 at "Science Advances"
DOI: 10.1126/sciadv.aaw9180
Abstract: A chemical approach enables the rapid mapping of CoA metabolites in complex biological systems. Metabolic engineering uses enzymes to produce small molecules with industrial, pharmaceutical, and energy applications. However, efforts to optimize enzymatic pathways for… read more here.
Keywords: hmg coa; cell free; mapping coa; coa metabolites ... See more keywords
The prognosis of lipid reprogramming with the HMG-CoA reductase inhibitor, rosuvastatin, in castrated Egyptian prostate cancer patients: Randomized trial
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DOI: 10.1371/journal.pone.0278282
Abstract: Aim The role of surgical castration and rosuvastatin treatment on lipid profile and lipid metabolism related markers was evaluated for their prognostic significance in metastatic prostate cancer (mPC) patients. Methods A total of 84 newly… read more here.
Keywords: hmg coa; rosuvastatin; coa reductase; prostate cancer ... See more keywords
Effects of Zingiber officinale hydro-alcoholic extract on HMG-COA reductase level in the testis of streptozotocin-induced diabetic rats
Sign Up to like & getrecommendations! Published in 2018 at "Journal of HerbMed Pharmacology"
DOI: 10.15171/jhp.2018.16
Abstract: Introduction: Zingiber officinale Roscoe, commonly known as ginger, is used as a cooking spice and therapeutically for its antioxidant and androgenic activities. We investigated the effects of Z. officinale hydro-alcoholic extract on HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme… read more here.
Keywords: diabetic rats; coa reductase; reductase level; hmg coa ... See more keywords