The FGFR inhibitor PD173074 binds to the C-terminus of oncofetal HMGA2 and modulates its DNA-binding and transcriptional activation functions.
Sign Up to like & getrecommendations! Published in 2023 at "FEBS letters"
DOI: 10.1002/1873-3468.14675
Abstract: The architectural chromatin factor high-mobility group AT-hook 2 (HMGA2) is causally involved in several human malignancies and pathologies. HMGA2 is not expressed in most normal adult somatic cells, which renders the protein an attractive drug… read more here.
Keywords: fgfr inhibitor; dna binding; hmga2; inhibitor pd173074 ... See more keywords
Long non‐coding RNA PCAT6 targets miR‐204 to modulate the chemoresistance of colorectal cancer cells to 5‐fluorouracil‐based treatment through HMGA2 signaling
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Medicine"
DOI: 10.1002/cam4.1809
Abstract: Colorectal cancer (CRC) is still the third most common cancer in the world with a limited prognosis due to the chemoresistance of CRC cells to 5‐fluorouracil (5‐FU)‐based chemotherapy. In our previous study, we revealed that… read more here.
Keywords: chemoresistance; colorectal cancer; hmga2; crc ... See more keywords
CCN6 regulates IGF2BP2 and HMGA2 signaling in metaplastic carcinomas of the breast
Sign Up to like & getrecommendations! Published in 2018 at "Breast Cancer Research and Treatment"
DOI: 10.1007/s10549-018-4960-2
Abstract: PurposeMetaplastic breast carcinomas are an aggressive subtype of triple-negative breast cancer (TNBC) in which part or all of the adenocarcinoma transforms into a non-glandular component (e.g., spindled, squamous, or heterologous). We discovered that mammary-specific Ccn6/Wisp3… read more here.
Keywords: breast; ccn6; igf2bp2 hmga2; hmga2 ... See more keywords
Metformin, a first‐line drug for type 2 diabetes mellitus, disrupts the MALAT1/miR‐142‐3p sponge to decrease invasion and migration in cervical cancer cells
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.04.027
Abstract: Abstract The molecular mechanisms underlying the anti‐neoplastic properties of metformin, a first‐line drug for type 2 diabetes, remain elusive. To explore the novel anti‐neoplastic mechanisms of metformin, the transwell chamber and wound‐healing assays were used… read more here.
Keywords: cervical cancer; mir 142; hmga2; migration ... See more keywords
The protective effect of high mobility group protein HMGA2 in pressure overload-induced cardiac remodeling.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2019.01.027
Abstract: High mobility group protein AT-hook 2 (HMGA2), an architectural transcription factor, has previously been reported to play an essential role in regulating the expression of many genes through architectural remodeling processes. However, the effects of… read more here.
Keywords: cardiac remodeling; high mobility; pressure overload; hmga2 ... See more keywords
Exploring the Conformational and Binding Dynamics of HMGA2·DNA Complexes Using Trapped Ion Mobility Spectrometry-Mass Spectrometry.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Society for Mass Spectrometry"
DOI: 10.1021/jasms.2c00101
Abstract: The mammalian high mobility group protein AT-hook 2 (HMGA2) is an intrinsically disordered DNA-binding protein expressed during embryogenesis. In the present work, the conformational and binding dynamics of HMGA2 and HMGA2 in complex with a… read more here.
Keywords: dna; mobility; mass spectrometry; hmga2 ... See more keywords
High expression of HMGA2 independently predicts poor clinical outcomes in acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2018 at "Blood Cancer Journal"
DOI: 10.1038/s41408-018-0103-6
Abstract: In acute myeloid leukemia (AML), risk stratification based on cytogenetics and mutation profiling is essential but remains insufficient to select the optimal therapy. Accurate biomarkers are needed to improve prognostic assessment. We analyzed RNA sequencing… read more here.
Keywords: clinical outcomes; myeloid leukemia; hmga2; expression ... See more keywords
The pro-migration and anti-apoptosis effects of HMGA2 in HUVECs stimulated by hypoxia
Sign Up to like & getrecommendations! Published in 2020 at "Cell Cycle"
DOI: 10.1080/15384101.2020.1850970
Abstract: ABSTRACT High-mobility group AT-hook2 (HMGA2), serving as an architectural transcription factor, participates in plenty of biological processes. Our study is aimed at illustrating the effect of HMGA2 on hypoxia-induced HUVEC injury and the underlying mechanism.… read more here.
Keywords: apoptosis; hmga2; migration; huvecs ... See more keywords
Downregulation of long non-coding RNA PVT1 enhances fracture healing via regulating microRNA-497-5p/HMGA2 axis.
Sign Up to like & getrecommendations! Published in 2021 at "Bioengineered"
DOI: 10.1080/21655979.2021.1987099
Abstract: Fragility fracture is a common and serious complication of osteoporosis. Abnormal expression of long non-coding RNAs is closely related to orthopedic diseases and bone metabolism. In the study, the role of lncRNA PVT1 during fracture… read more here.
Keywords: fracture; pvt1; mir 497; hmga2 ... See more keywords
Circular RNA CircSHKBP1 accelerates the proliferation, invasion, angiogenesis, and stem cell-like properties via modulation of microR-766-5p/high mobility group AT-hook 2 axis in laryngeal squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2068922
Abstract: ABSTRACT Laryngeal squamous cell carcinoma (LSCC) is a common malignancy in head and neck. Circular SHKBP1 (circSHKBP) exerts momentous functions in the occurrence of many cancers including LSCC. Thus, we investigated the oncogenic capacities of… read more here.
Keywords: cell; mir 766; hmga2; circshkbp1 ... See more keywords
Hepatitis B virus X protein promotes hepatocarcinogenesis via the activation of HMGA2/STC2 signaling to counteract oxidative stress-induced cell death.
Sign Up to like & getrecommendations! Published in 2022 at "Carcinogenesis"
DOI: 10.1093/carcin/bgac030
Abstract: Chronic hepatitis B virus (HBV) infection can cause oxidative stress and induce cell death. The mechanisms by which cells overcome oxidative stress to survive remain largely unknown. Here, we used human sera, liver tissues and… read more here.
Keywords: cell death; hmga2; hmga2 stc2; oxidative stress ... See more keywords