Ketamine delays progression of oxidative and damaged cataract through regulating HMGB-1/NF-κB in lens epithelial cells
Sign Up to like & getrecommendations! Published in 2018 at "Immunopharmacology and Immunotoxicology"
DOI: 10.1080/08923973.2018.1478851
Abstract: Abstract Objective: Lens epithelial cell (LEC) membrane damage is one of the pathogenesis of cataract. High mobility group box-1 (HMGB-1) and nuclear factor-κB (NF-κB) play vital roles in a variety of diseases, such as inflammation.… read more here.
Keywords: lens epithelial; group; model group; cataract ... See more keywords
High‐mobility group box‐1 promotes vascular calcification in diabetic mice via endoplasmic reticulum stress
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.16075
Abstract: Several studies reported the role of endoplasmic reticulum stress (ERS) in vascular calcification. High‐mobility group box‐1 (HMGB‐1) plays a substantial role in diabetes and its complications. However, relatively little information is available regarding the association… read more here.
Keywords: endoplasmic reticulum; vascular calcification; calcification; diabetic mice ... See more keywords
Extracellular HMGB-1 activates inflammatory signaling in tendon cells and tissues
Sign Up to like & getrecommendations! Published in 2020 at "Therapeutic Advances in Chronic Disease"
DOI: 10.1177/2040622320956429
Abstract: Background: Increasing evidence indicates that secretion of high mobility group box 1 protein (HMGB-1) is functionally associated with tendinopathy development. However, the underlying effect and mechanism of extracellular HMGB-1 on tendon cells are unclear. Methods:… read more here.
Keywords: tendon tissues; inflammatory signaling; extracellular hmgb; tendon cells ... See more keywords
Evaluation of Graft Effluent High Mobility Group Box-1 (HMGB-1) for Prediction of Outcome After Liver Transplantation
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DOI: 10.12659/aot.909165
Abstract: Background Pre-transplant assessment of the graft for liver transplantation is crucial. Based on experimental data, this study was designed to assess both nuclear high mobility group box-1 (HMGB-1) protein and arginine-specific proteolytic activity (ASPA) in… read more here.
Keywords: graft; liver transplantation; graft effluent; hmgb ... See more keywords
Activation of Peripheral Blood Mononuclear Cells and Leptin Secretion: New Potential Role of Interleukin-2 and High Mobility Group Box (HMGB)1
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DOI: 10.3390/ijms22157988
Abstract: Activation of innate immunity and low-grade inflammation contributes to hyperglycemia and an onset of Type 2 Diabetes Mellitus (T2DM). Interleukin-2 (IL-2), leptin, High Mobility Group Box-1 (HMGB-1), and increased glucose concentrations are mediators of these… read more here.
Keywords: secretion; high mobility; group box; mobility group ... See more keywords