ENSMUST00000147869 regulates proliferation and fibrosis of mesangial cells in diabetic nephropathy by interacting with Hspa9
Sign Up to like & getrecommendations! Published in 2022 at "IUBMB Life"
DOI: 10.1002/iub.2599
Abstract: Our previous study showed that ENSMUST00000147869 was abnormally low expressed in the early stage of diabetic nephropathy (DN). ENSMUST00000147869 could inhibit the fibrosis and proliferation of mouse mesangial cells (MMCs), but the mechanism is still… read more here.
Keywords: ensmust00000147869 regulates; ensmust00000147869; proliferation fibrosis; hspa9 ... See more keywords
MiR-101-3p inhibits MTX-mediated HMGB1 release and reduces recruitment and M1-like polarization of macrophages through the UBE2D1/KAT2B pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.22987
Abstract: The results of recent studies have shown that miRNAs play a vital role in tumor microenvironment during Methotrexate (MTX) chemotherapy. In this study, we investigated the possible miRNA changes and their effect of MTX on… read more here.
Keywords: like polarization; ube2d1 kat2b; macrophages ube2d1; hmgb1 ... See more keywords
High Mobility Group Box 1 Mediates Interferon‐γ‐Induced Phenotypic Modulation of Vascular Smooth Muscle Cells
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DOI: 10.1002/jcb.25682
Abstract: The phenotypic modulation of VSMCs is a key cellular event driving neointimal formation and vascular remodeling. As a multifaceted cytokine of cell‐mediated immunity, IFN‐γ has been shown to play a critical role in the pathogenesis… read more here.
Keywords: hmgb1; modulation; ifn; phenotypic modulation ... See more keywords
The Role of Serum High Mobility Group Box 1 and Interleukin‐6 Levels in Acute Pancreatitis: A Meta‐Analysis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26222
Abstract: The purpose of this meta‐analysis was to comprehensively investigate the correlation between high mobility group box 1 (HMGB1) and interleukin‐6 (IL‐6) in relation to acute pancreatitis. A highly regulated exploration of various electronic databases, supplemented… read more here.
Keywords: acute pancreatitis; analysis; hmgb1; meta analysis ... See more keywords
HMGB1‐induced inflammatory response promotes bone healing in murine tooth extraction socket
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26710
Abstract: High mobility group box 1 (HMGB1) is a non‐histone DNA‐binding protein that is secreted into the extracellular milieu in response to inflammatory stimuli. The secreted HMGB1 has been suggested to mediate various inflammatory diseases. However,… read more here.
Keywords: hmgb1; tooth extraction; extraction socket; anti hmgb1 ... See more keywords
miR‐505 acts as a tumor suppressor in gastric cancer progression through targeting HMGB1
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28082
Abstract: Gastric cancer (GC) is a frequent type of malignant tumor worldwide. GC metastasis results in the majority of clinical treatment failures. MicroRNAs (miRNA) are identified to exhibit crucial roles in GC. Our current study aimed… read more here.
Keywords: hmgb1; mir 505; gastric cancer; mir ... See more keywords
Effects of nebulized N‐acetylcystein on the expression of HMGB1 and RAGE in rats with hyperoxia‐induced lung injury
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27724
Abstract: To investigate the role of high mobility group box 1 (HMGB1) and receptor for advanced glycation end product (RAGE) in the lungs of hyperoxia‐induced rats and the effect of N‐acetlycystein (NAC). read more here.
Keywords: hmgb1; hyperoxia induced; effects nebulized; rage ... See more keywords
Exploring the role of high-mobility group box 1 (HMGB1) protein in the pathogenesis of Huntington’s disease
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Medicine"
DOI: 10.1007/s00109-020-01885-z
Abstract: Huntington’s disease (HD) is an autosomal-dominant neurodegenerative disorder caused by an increased and unstable CAG DNA expansion in the Huntingtin ( HTT ) gene, resulting in an elongated polyglutamine tract in huntingtin protein. Despite its… read more here.
Keywords: hmgb1; protein; disease; pathogenesis ... See more keywords
Survival of the fittest: how myeloid-derived suppressor cells survive in the inhospitable tumor microenvironment
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-019-02388-8
Abstract: Myeloid-derived suppressor cells (MDSC) are present in most cancer patients where they are significant contributors to the immune suppressive tumor microenvironment (TME). The TME is a hostile locale due to deficiencies in oxygen (hypoxia) and… read more here.
Keywords: hmgb1; suppressor cells; derived suppressor; tumor microenvironment ... See more keywords
Up-regulation of HMGB1 and TLR4 in skin lesions of lichen planus
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DOI: 10.1007/s00403-018-1837-5
Abstract: Lichen planus (LP) is a chronic, mucocutaneous inflammatory disease of an unknown aetiology. The disease has been associated with certain viruses, and the factors such as DAMPs (damage-associated molecular patterns) and PAMPs (pathogen-associated molecular patterns)… read more here.
Keywords: hmgb1; skin lesions; hmgb1 tlr4; lichen planus ... See more keywords
High-sensitivity C-reactive protein and high mobility group box-1 levels in Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2018 at "Neurological Sciences"
DOI: 10.1007/s10072-018-3611-z
Abstract: Various immunologic and inflammatory factors are contributed to pathogenesis of Parkinson’s disease (PD). High mobility group box-1 (HMGB1) is a protein that plays certain roles in inflammation, DNA repair, transcription, somatic recombination, cell differentiation, cell… read more here.
Keywords: hmgb1; hmgb1 crp; group; sensitivity ... See more keywords