Elevated expression of HMGB1 is prognostic of poor survival in patients with relapsed/refractory T/NK-CL
Sign Up to like & getrecommendations! Published in 2021 at "Annals of Hematology"
DOI: 10.1007/s00277-021-04473-4
Abstract: Despite the clinical value of HMGB1 in non-Hodgkin lymphoma (NHL), the impact of HMGB1 protein expression on survival of patients with mature T-cell and NK-cell lymphoma (T/NK-CL) is unknown. Here, we evaluated correlations of HMGB1… read more here.
Keywords: relapsed refractory; hmgb1 expression; expression; high hmgb1 ... See more keywords
Identification of High-Mobility Group Box 1 (HMGB1) Expression as a Potential Predictor of Rejection and Poor Prognosis After Liver Transplantation
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DOI: 10.12659/aot.931625
Abstract: Background Acute cellular rejection (ACR) frequently occurs after liver transplantation (LT) and can result in permanent damage of the liver allograft. Specific and sensitive biomarkers for predicting and monitoring ACR are vital for guiding post-transplantation… read more here.
Keywords: prognosis; hmgb1 expression; rejection; hmgb1 ... See more keywords
Subcellular Epithelial HMGB1 Expression Is Associated with Colorectal Neoplastic Progression, Male Sex, Mismatch Repair Protein Expression, Lymph Node Positivity, and an ‘Immune Cold’ Phenotype Associated with Poor Survival
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DOI: 10.3390/cancers15061865
Abstract: Simple Summary New treatment targets are urgently needed for colorectal cancer. Here, we investigate the role of HMGB1—a multifunctional immune protein—in colorectal cancer. We demonstrate dynamic subcellular (nuclear and cytoplasmic) HMGB1 expression in lesions seen… read more here.
Keywords: progression; expression; colorectal cancer; hmgb1 expression ... See more keywords
Platinum-Based Regimens Are Active in Advanced Pediatric-Type Rhabdomyosarcoma in Adults and Depending on HMGB1 Expression
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DOI: 10.3390/ijms24010856
Abstract: Rhabdomyosarcoma (RMS) in adults is a rare and aggressive disease, which lacks standard therapies for relapsed or advanced disease. This retrospective study aimed to describe the activity of BOMP-EPI (bleomycin, vincristine, methotrexate and cisplatin alternating… read more here.
Keywords: pediatric type; hmgb1 expression; response; rhabdomyosarcoma ... See more keywords
Inhibitory effects of miR-25 targeting HMGB1 on macrophage secretion of inflammatory cytokines in sepsis
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DOI: 10.3892/ol.2018.9308
Abstract: High mobility group box 1 (HMGB1) can promote the migration of macrophages and the release of inflammatory cytokines, functions associated with the occurrence of sepsis. The role of microRNA (miR)-25 in the targeted regulation of… read more here.
Keywords: hmgb1; sepsis; mir; inflammatory cytokines ... See more keywords