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HMGB1 gene silencing inhibits neuroinflammation via down-regulation of NF-κB signaling in primary hippocampal neurons induced by Aβ25-35.

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0 Published in 2019 at "International immunopharmacology"

DOI: 10.1016/j.intimp.2018.12.027

Abstract: High mobility group box 1 protein (HMGB1) is potentially triggered by Aβ oligomers and other sterile injuries, and is a non-histone DNA binding nuclear protein with roles in neural development and neurodegeneration, which contribute to… read more here.

Keywords: hmgb1; hippocampal neurons; neuroinflammation; hmgb1 gene ... See more keywords

Molecular and Thermodynamic Studies on DNA Triplex Formed in the Promoter Region of HMGB1 Gene as a Selective Target for Anticancer Drugs.

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1 Published in 2017 at "Anti-cancer agents in medicinal chemistry"

DOI: 10.2174/1871520617666170213142619

Abstract: BACKGROUND HMGB1 (High Mobility Group Box-1) is a very versatile highly abundant architectural protein that plays multiple roles in human health and diseases. Under physiological condition it serves as an amazing assortment of roles in… read more here.

Keywords: hmgb1; promoter region; hmgb1 gene; region hmgb1 ... See more keywords

Antigene and Antiproliferative Effects of Triplex-Forming Oligonucleotide (TFO) Targeted on hmgb1 Gene in Human Hepatoma Cells.

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0 Published in 2020 at "Anti-cancer agents in medicinal chemistry"

DOI: 10.2174/1871520620666200619170438

Abstract: BACKGROUND The high mobility group box 1 (hmgb1) is one of the frequently over-expressed genes whose aberrant expression is reported in a number of human cancers. Various strategies are underway to inhibit hmgb1 expression in… read more here.

Keywords: forming oligonucleotide; hmgb1 gene; triplex forming; tfo ... See more keywords

Association of HMGB1 Gene Polymorphisms with Lung Cancer Susceptibility and Clinical Aspects

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0 Published in 2017 at "International Journal of Medical Sciences"

DOI: 10.7150/ijms.20933

Abstract: Lung cancer is one of the most frequently diagnosed malignancies and is associated with a poor survival rate in the Chinese Han population. Analysis of genetic variants could lead to improvements in prognosis following lung… read more here.

Keywords: cancer; hmgb1 gene; lung cancer;