Barrier protective functions of hederacolchiside-E against HMGB1-mediated septic responses.
Sign Up to like & getrecommendations! Published in 2020 at "Pharmacological research"
DOI: 10.1016/j.phrs.2020.105318
Abstract: The role of high mobility group box 1 (HMGB1) has been recognized as important, and suppression of HMGB1 release and restoration of vascular barrier integrity are regarded as potentially promising therapeutic strategies against sepsis. Hederacolchiside-E… read more here.
Keywords: hmgb1; sepsis; hmgb1 mediated; hmgb1 release ... See more keywords
RSV Infection Promotes Necroptosis and HMGB1 Release by Airway Epithelial Cells.
Sign Up to like & getrecommendations! Published in 2020 at "American journal of respiratory and critical care medicine"
DOI: 10.1164/rccm.201906-1149oc
Abstract: RATIONALE RSV bronchiolitis causes significant infant mortality. Bronchiolitis is characterised by airway epithelial cell (AEC) death, however the mode of death remains unknown. OBJECTIVES To determine whether necroptosis contributes to RSV bronchiolitis pathogenesis via high… read more here.
Keywords: hmgb1 release; infection; rsv infection; release ... See more keywords
MLKL Regulates Rapid Cell Death-independent HMGB1 Release in RSV Infected Airway Epithelial Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.890389
Abstract: Respiratory syncytial virus (RSV)-induced bronchiolitis is a significant contributor to infant morbidity and mortality. Previously, we identified that necroptosis, a pro-inflammatory form of cell death mediated by receptor-interacting serine/threonine-protein kinase 1 (RIPK1) and RIPK3, and… read more here.
Keywords: cell death; rsv; hmgb1 release; release ... See more keywords
Glycyrrhizin Protects Mice Against Experimental Autoimmune Encephalomyelitis by Inhibiting High-Mobility Group Box 1 (HMGB1) Expression and Neuronal HMGB1 Release
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.01518
Abstract: The inflammatory mediator high-mobility group box 1 (HMGB1) plays a critical role in the pathogenesis of human multiple sclerosis (MS) and mouse experimental autoimmune encephalomyelitis (EAE). Glycyrrhizin (GL), a glycoconjugated triterpene extracted from licorice root,… read more here.
Keywords: hmgb1; high mobility; group box; hmgb1 release ... See more keywords
N-Acetyl Cysteine Restores Sirtuin-6 and Decreases HMGB1 Release Following Lipopolysaccharide-Sensitized Hypoxic-Ischemic Brain Injury in Neonatal Mice
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2021.743093
Abstract: Inflammation and neonatal hypoxia-ischemia (HI) are important etiological factors of perinatal brain injury. However, underlying mechanisms remain unclear. Sirtuins are a family of nicotinamide adenine dinucleotide (NAD)+-dependent histone deacetylases. Sirtuin-6 is thought to regulate inflammatory… read more here.
Keywords: release; brain injury; brain; hmgb1 release ... See more keywords