Protective effect of pinocembrin from Penthorum chinense Pursh on hepatic ischemia reperfusion injury via regulating HMGB1/TLR4 signal pathway
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7605
Abstract: Hepatic ischemia–reperfusion injury (HIRI) is of common occurrence during liver surgery and transplantation. Pinocembrin (PIN) is a kind of flavonoid monomer extracted from the local traditional Chinese medicine Penthorum chinense Pursh (P. chinense). However, the… read more here.
Keywords: effect; hmgb1 tlr4; hepatic ischemia; chinense ... See more keywords
Up-regulation of HMGB1 and TLR4 in skin lesions of lichen planus
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Dermatological Research"
DOI: 10.1007/s00403-018-1837-5
Abstract: Lichen planus (LP) is a chronic, mucocutaneous inflammatory disease of an unknown aetiology. The disease has been associated with certain viruses, and the factors such as DAMPs (damage-associated molecular patterns) and PAMPs (pathogen-associated molecular patterns)… read more here.
Keywords: hmgb1; skin lesions; hmgb1 tlr4; lichen planus ... See more keywords
Diacerein ameliorates acetaminophen hepatotoxicity in rats via inhibiting HMGB1/TLR4/NF-κB and upregulating PPAR-γ signal.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular biology reports"
DOI: 10.1007/s11033-022-07366-5
Abstract: BACKGROUND Acetaminophen (APAP) is a worldwide antipyretic as well as an analgesic medication. It has been extensively utilized during the outbreak of coronavirus 2019 (COVID-19). APAP misuse would lead to liver injury. Diacerein (DIA), an… read more here.
Keywords: tlr4; expression; liver injury; diacerein ... See more keywords
Neonatal Streptococcus Pneumoniae pneumonia induces airway SMMHC expression through HMGB1/TLR4/ERK.
Sign Up to like & getrecommendations! Published in 2021 at "Immunology letters"
DOI: 10.1016/j.imlet.2021.10.005
Abstract: BACKGROUND Our previous study showed that neonatal S. pneumoniae pneumonia promoted airway smooth muscle myosin heavy chain (SMMHC) expression and AHR development. Researches demonstrated HMGB1, TLR4 and ERK are involved in smooth muscle contractile protein… read more here.
Keywords: expression; pneumoniae pneumonia; hmgb1 tlr4; pneumonia ... See more keywords
Rosmarinic acid attenuates inflammatory responses through inhibiting HMGB1/TLR4/NF‐&kgr;B signaling pathway in a mouse model of Parkinson's disease
Sign Up to like & getrecommendations! Published in 2019 at "Life Sciences"
DOI: 10.1016/j.lfs.2019.03.030
Abstract: Abstract Inflammation contributes to the pathological processes in patients and animal models of PD. Rosmarinic acid (RA) has been demonstrated to protect neurons in PD models. The present study aimed to evaluate the anti‐inflammatory effect… read more here.
Keywords: inflammatory responses; hmgb1 tlr4; rosmarinic acid; kgr signaling ... See more keywords
Immunomodulatory effect of Celecoxib on HMGB1/TLR4 pathway in a recurrent seizures model in immature rats
Sign Up to like & getrecommendations! Published in 2018 at "Pharmacology Biochemistry and Behavior"
DOI: 10.1016/j.pbb.2018.05.007
Abstract: ABSTRACT Epileptic seizures constitute an important problem in pediatric neurology during the developmental period. The frequency and nosological significance of seizures, as well as their association with epileptogenesis, may be related to underlying mechanisms such… read more here.
Keywords: hmgb1; hmgb1 tlr4; treatment; tlr4 pathway ... See more keywords
HMGB1/TLR4 promotes hypoxic pulmonary hypertension via suppressing BMPR2 signaling.
Sign Up to like & getrecommendations! Published in 2019 at "Vascular pharmacology"
DOI: 10.1016/j.vph.2018.12.006
Abstract: High mobility group box 1 (HMGB1), a critical nonclassical inflammatory cytokine, has been found up-regulated in patients with idiopathic pulmonary arterial hypertension (IPAH), but its role in vascular remodeling of pulmonary hypertension (PH) is still… read more here.
Keywords: hmgb1 tlr4; pulmonary hypertension; hypertension; bmpr2 signaling ... See more keywords
Allergen-specific immunotherapy with Alutard SQ improves allergic inflammation in house-dust mites-induced allergic asthma rats through inactivation of the HMGB1/TLR4/NF-κB pathway
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Thoracic Disease"
DOI: 10.21037/jtd-22-715
Abstract: Background Allergen-specific immunotherapy (AIT) is the only available safe, effective, and long-term treatment for allergic airway diseases, including allergic asthma. However, the potential molecular mechanism of AIT in ameliorating airway inflammation remains unknown. Methods Rats… read more here.
Keywords: allergen specific; allergic asthma; house dust; specific immunotherapy ... See more keywords
Serum Sirtuin-1, HMGB1-TLR4, NF-KB and IL-6 levels in Alzheimer's: The Relation Between Neuroinflammatory Pathway and Severity of Dementia.
Sign Up to like & getrecommendations! Published in 2022 at "Current Alzheimer research"
DOI: 10.2174/1567205020666221226140721
Abstract: Alzheimer's disease (AD), which affects the world's aging population, is a progressive neurodegenerative disease requiring markers or tools to accurately and easily diagnose and monitor the process accurately and easily. OBJECTIVE In this study, serum… read more here.
Keywords: tlr4 levels; hmgb1 tlr4; serum sirtuin; dementia ... See more keywords
Role of HMGB1/TLR4 and IL-1β/IL-1R1 Signaling Pathways in Epilepsy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2022.904225
Abstract: Epilepsy is a chronic disorder of the nervous system characterized by recurrent seizures. Inflammation is one of the six major causes of epilepsy, and its role in the pathogenesis of epilepsy is gaining increasing attention.… read more here.
Keywords: role hmgb1; hmgb1 tlr4; tlr4 1r1; epilepsy ... See more keywords
Catalpol Protects Against Spinal Cord Injury in Mice Through Regulating MicroRNA-142-Mediated HMGB1/TLR4/NF-κB Signaling Pathway
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.630222
Abstract: Background: Spinal cord injury (SCI) is a devastating condition that leads to paralysis, disability and even death in severe cases. Inflammation, apoptosis and oxidative stress in neurons are key pathogenic processes in SCI. Catalpol (CTP),… read more here.
Keywords: apoptosis; hmgb1 tlr4; mice; spinal cord ... See more keywords