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   Articles with "hmgcs2" as a keyword



HMGCS2 promotes autophagic degradation of the amyloid-β precursor protein through ketone body-mediated mechanisms.

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recommendations! Published in 2017 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2017.03.069

Abstract: HMGCS2 (mitochondrial 3-hydroxy-3-methylglutaryl-COA synthase 2) is a control enzyme in ketogenesis. The mitochondrial localization and interaction with APP (β-amyloid precursor protein) suggest that HMGCS2 may play a role in the pathophysiology of AD (Alzheimer's disease).… read more here.

Keywords: precursor protein; hmgcs2; lc3ii; amyloid precursor ... See more keywords
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Hmgcs2-mediated ketogenesis modulates high-fat diet-induced hepatosteatosis

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recommendations! Published in 2022 at "Molecular Metabolism"

DOI: 10.1016/j.molmet.2022.101494

Abstract: Objective Aberrant ketogenesis is correlated with the degree of steatosis in non-alcoholic fatty liver disease (NAFLD) patients, and an inborn error of ketogenesis (mitochondrial HMG-CoA synthase deficiency) is commonly associated with the development of the… read more here.

Keywords: ketogenesis; hmgcs2; development; hmgcs2 mediated ... See more keywords

Abstract 4136030: Fatty acids disturb cardiomyocyte proliferation by increasing PDK4 and HMGCS2 via PPARδ activation

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recommendations! Published in 2024 at "Circulation"

DOI: 10.1161/circ.150.suppl_1.4136030

Abstract: Background: Almost all cardiac diseases are difficult to cure entirely because cardiomyocytes rarely proliferate to recover cardiac damage. In fact, most mammals have a capacity to regenerate cardiomyocytes immediately after birth. Newborn infant drastically changes… read more here.

Keywords: ppar; hmgcs2; fatty acids; metabolism ... See more keywords

JAK2/STAT3/HMGCS2 signaling aggravates mitochondrial dysfunction and oxidative stress in hyperuricemia-induced cardiac dysfunction

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recommendations! Published in 2025 at "Molecular Medicine"

DOI: 10.1186/s10020-025-01246-x

Abstract: High uric acid levels play a critical role in cardiovascular disease pathophysiology, being closely linked to their occurrence, progression, and prognosis. To enhance prevention and treatment of hyperuricemia-related cardiovascular diseases, understanding underlying mechanisms and identifying… read more here.

Keywords: hmgcs2; oxidative stress; jak2 stat3; dysfunction ... See more keywords

Targeting HMGCS2: Ketogenesis Suppression Accelerates NAFLD Progression in T2DM Comorbidity, While Cynaroside Ameliorates NASH in Concomitant T2DM

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recommendations! Published in 2025 at "Biomolecules"

DOI: 10.3390/biom15081181

Abstract: Patients with concurrent non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) exhibit increased susceptibility to non-alcoholic steatohepatitis (NASH), advanced hepatic fibrosis, cirrhosis, and hepatocellular carcinoma. This study investigated the contribution of ketogenesis… read more here.

Keywords: t2dm; hmgcs2; ketogenesis; nafld progression ... See more keywords

Loss of HMGCS2 Enhances Lipogenesis and Attenuates the Protective Effect of the Ketogenic Diet in Liver Cancer

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recommendations! Published in 2020 at "Cancers"

DOI: 10.3390/cancers12071797

Abstract: Hepatocellular carcinoma (HCC) is the most common primary malignant liver tumor with limited treatment. The ketogenic diet (KD) emerged as a metabolic therapy for cancer; however, the antitumor effect on HCC remains controversial. We previously… read more here.

Keywords: effect; hmgcs2; attenuates protective; cancer ... See more keywords

Recurrent loss of HMGCS2 shows that ketogenesis is not essential for the evolution of large mammalian brains

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recommendations! Published in 2018 at "eLife"

DOI: 10.7554/elife.38906

Abstract: Apart from glucose, fatty acid-derived ketone bodies provide metabolic energy for the brain during fasting and neonatal development. We investigated the evolution of HMGCS2, the key enzyme required for ketone body biosynthesis (ketogenesis). Unexpectedly, we… read more here.

Keywords: evolution; evolution large; large mammalian; ketogenesis ... See more keywords