Inducible Knockout of HMGN1 in an In Vivo xenograft Model Reduces Down Syndrome Leukemic Burden and Increases Survival Outcomes
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DOI: 10.1182/blood-2020-138620
Abstract: Introduction Down Syndrome (DS) patients are at high risk of developing hematological malignancies and ~10% are born with a pre-leukemic disorder characterised by the overproduction of immature megakaryoblasts. Children with DS have a 20-fold increased… read more here.
Keywords: hmgn1; jak2 hmgn1; mice; hmgn1 mice ... See more keywords