RNAi silencing of the 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) gene inhibits vitellogenesis in Chinese mitten crab Eriocheir sinensis.
Sign Up to like & getrecommendations! Published in 2021 at "Comparative biochemistry and physiology. Part A, Molecular & integrative physiology"
DOI: 10.1016/j.cbpa.2021.111078
Abstract: The sesquiterpenoid methyl farnesoate (MF), a de-epoxide form of insect juvenile hormone III (JH III), plays an essential role in regulating many crucial physiological processes in crustaceans including vitellogenesis and reproduction. 3-hydroxy-3-methylglutaryl coenzyme A reductase… read more here.
Keywords: sinensis; eshmgr; physiology; hydroxy methylglutaryl ... See more keywords
HMG-CoA Reductase Inhibitors as Drug Leads against Naegleria fowleri.
Sign Up to like & getrecommendations! Published in 2020 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.0c00428
Abstract: Primary amebic meningoencephalitis (PAM), caused by the free-living ameba Naegleria fowleri, has a fatality rate of over 97%. Treatment of PAM relies on amphotericin B in combination with other drugs, but few patients have survived… read more here.
Keywords: hmg coa; fowleri; naegleria fowleri; drug ... See more keywords