Articles with "hml" as a keyword



Antibody Response to HML‐2 May Be Protective in Amyotrophic Lateral Sclerosis

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Published in 2022 at "Annals of Neurology"

DOI: 10.1002/ana.26466

Abstract: Reactivation of HERV‐K(HML‐2) has been found in subsets of individuals with amyotrophic lateral sclerosis (ALS). This study examines the antibody response against HML‐2 in ALS and analyzes its clinical relevance. read more here.

Keywords: amyotrophic lateral; antibody response; hml; lateral sclerosis ... See more keywords

Limits to Transcriptional Silencing in Saccharomyces cerevisiae.

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Published in 2022 at "Genetics"

DOI: 10.1093/genetics/iyac180

Abstract: Mating-type switching in the budding yeast Saccharomyces cerevisiae relies on the Sir protein complex to silence HML and HMR, the two loci containing copies of the alleles of the mating type locus, MAT. Sir-based transcriptional… read more here.

Keywords: locus; hml; transcriptional silencing; gene ... See more keywords

HML-RF: Hybrid Multi-Label Random Forest

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Published in 2022 at "IEEE Access"

DOI: 10.1109/access.2022.3154420

Abstract: Multi-label classification is the supervised learning problem in which an instance is associated with a set of labels. In this, labels are correlated, and hence label dependency information plays a vital role. Its always been… read more here.

Keywords: problem; hybrid multi; hml; multi label ... See more keywords

Evaluation of full-fatted and hydrolysate mealworm (Tenebrio molitor) larvae as a substitute for spray-dried plasma protein diet in weaning pigs.

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Published in 2022 at "Journal of animal physiology and animal nutrition"

DOI: 10.1111/jpn.13763

Abstract: The goal of this experiment was to examine the effect of dietary inclusion of full-fatted mealworm larvae (FFML) or hydrolysate mealworm larvae (HML) (Tenebrio molitor) as a substitute for spray-dried plasma protein (SDPP) as a… read more here.

Keywords: hydrolysate mealworm; sdpp; con; hml ... See more keywords

p53 Binding Sites in Long Terminal Repeat 5Hs (LTR5Hs) of Human Endogenous Retrovirus K Family (HML-2 Subgroup) Play Important Roles in the Regulation of LTR5Hs Transcriptional Activity

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Published in 2022 at "Microbiology Spectrum"

DOI: 10.1128/spectrum.00485-22

Abstract: Human endogenous retroviruses (HERVs) were integrated into the human genome in ancient times and have been coevolving with the host. Since the Human Genome Project, HERVs have attracted increasing attention. ABSTRACT The long terminal repeats… read more here.

Keywords: human endogenous; transcriptional activity; hml; activity ... See more keywords

Human endogenous retrovirus HERV-K(HML-2) RNA causes neurodegeneration through Toll-like receptors.

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Published in 2020 at "JCI insight"

DOI: 10.1172/jci.insight.131093

Abstract: Although human endogenous retroviruses (HERVs) represent a substantial proportion of the human genome and some HERVs, such as HERV-K(HML-2), are reported to be involved in neurological disorders, little is known about their biological function. We… read more here.

Keywords: human endogenous; hml rna; hml; herv hml ... See more keywords

Comprehensive characterization of ERV-K (HML-8) in the chimpanzee genome revealed less genomic activity than humans

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Published in 2024 at "Frontiers in Cellular and Infection Microbiology"

DOI: 10.3389/fcimb.2024.1349046

Abstract: Endogenous retroviruses (ERVs) originate from ancestral germline infections caused by exogenous retroviruses. Throughout evolution, they have become fixed within the genome of the animals into which they were integrated. As ERV elements coevolve with the… read more here.

Keywords: integration; hml; genome; activity ... See more keywords

Association Between Activated Loci of HML-2 Primate-Specific Endogenous Retrovirus and Newly Formed Chromatin Contacts in Human Primordial Germ Cell-like Cells

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Published in 2024 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms252413639

Abstract: The pluripotent stem cell (PSC)-derived human primordial germ cell-like cells (PGCLCs) are a cell culture-derived surrogate model of embryonic primordial germ cells. Upon differentiation of PSCs to PGCLCs, multiple loci of HML-2, the hominoid-specific human… read more here.

Keywords: pgclcs; chromatin contacts; hml; germ ... See more keywords