Young transgenic hMTH1 mice are protected against dietary fat‐induced metabolic stress—implications for enhanced longevity
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DOI: 10.1111/acel.13605
Abstract: hMTH1 protects against mutation during oxidative stress. It degrades 8‐oxodGTP to exclude potentially mutagenic oxidized guanine from DNA. hMTH1 expression is linked to ageing. Its downregulation in cultured cells accelerates RAS‐induced senescence, and its overexpression… read more here.
Keywords: stress; longevity; hmth1 mice; months old ... See more keywords