Nitrogen Mustard Alkylates and Cross-Links p53 in Human Keratinocytes.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.1c00420
Abstract: Cytotoxic blistering agents such as sulfur mustard and nitrogen mustard (HN2) were synthesized for chemical warfare. Toxicity is due to reactive chloroethyl side chains that modify and damage cellular macromolecules including DNA and proteins. In… read more here.
Keywords: cross links; dna; cross linked; nitrogen mustard ... See more keywords
Ebselen oxide attenuates mechlorethamine dermatotoxicity in the mouse ear vesicant model
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DOI: 10.1080/01480545.2018.1488858
Abstract: Abstract Mechlorethamine (HN2) is an alkylating agent and sulfur mustard mimetic. Topical exposure to HN2 is associated with tissue blistering. Previous work in our laboratory has shown that ebselen (EB-1) possesses anti-vesicant, anti-inflammatory, anti-bacterial, anti-fungal,… read more here.
Keywords: vesicant model; hn2; ebselen oxide; ear vesicant ... See more keywords
Next Generation Sequencing and Comparative Genomic Analysis Reveal Extreme Plasticity of Two Burkholderia glumae Strains HN1 and HN2
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DOI: 10.3390/pathogens11111265
Abstract: Burkholderia glumae is an important rice pathogen, thus the genomic and evolutionary history may be helpful to control this notorious pathogen. Here, we present two complete genomes of the B. glumae strains HN1 and HN2,… read more here.
Keywords: burkholderia glumae; strains hn1; hn1 hn2; analysis ... See more keywords