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Published in 2023 at "IUBMB life"
DOI: 10.1002/iub.2724
Abstract: The main factors contributing to the unfavorable outcome in the clinical treatment of patients with nasopharyngeal carcinoma (NPC) patients are radiation resistance and recurrence. This study aimed to investigate the sensitivity and molecular foundation of…
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Keywords:
cell;
apoptosis;
hne;
expression ... See more keywords
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Published in 2022 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.23087
Abstract: 4-Hydroxy-2-nonenal (HNE) is an inducer of inflammation. The aim of this study was to elicit the link between the inhibition of HNE accumulation and the depression of inflammation whether dependent onl-arginine availability in growing rats.…
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Keywords:
activation;
hydroxy nonenal;
hne;
arginine ... See more keywords
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Published in 2021 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-020-02684-4
Abstract: Herein we report our investigation concerning the development of Human neutrophil elastase (hNE) inhibitors for the treatment of Acute Respiratory Distress Syndrome (ARDS). Various benzenesulfonic acid derived compounds were synthesized and evaluated as competitive inhibitors…
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Keywords:
benzenesulfonic acid;
neutrophil elastase;
human neutrophil;
hne ... See more keywords
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Published in 2018 at "Clinical Colorectal Cancer"
DOI: 10.1016/j.clcc.2017.09.006
Abstract: Background: Köhne prognostic score is used to classify patients with metastatic colorectal cancer (mCRC) as high, intermediate, or low risk. Using data from 2 phase III trials, we analyzed survival in patients categorized according to…
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Keywords:
category braf;
category;
colorectal cancer;
hne prognostic ... See more keywords
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Published in 2019 at "Experimental eye research"
DOI: 10.1016/j.exer.2019.107792
Abstract: Oxidative stress and subsequent chronic inflammation result in dysfunction of the retinal pigment epithelium (RPE) and represent therapeutic targets in the context of age-related macular degeneration (AMD). However, molecular mechanisms that linked oxidative stress and…
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Keywords:
hsp70;
production;
rpe cells;
efflux ... See more keywords
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Published in 2017 at "Food chemistry"
DOI: 10.1016/j.foodchem.2017.01.035
Abstract: The compound 4-hydroxy-2-nonenal (HNE) dissolved in water was examined to remove potential effects of using ethanol to solubilize the aldehyde such as altering protein structure or redox properties of myoglobin (Mb). HNE became covalently bound…
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Keywords:
oxidation;
mediated lipid;
hemin affinity;
hydroxy nonenal ... See more keywords
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Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2016.10.490
Abstract: Abstract Oxidative stress is involved in various and numerous pathological states including several age‐related neurodegenerative diseases. Peroxidation of the membrane lipid bilayer is one of the major sources of free radical‐mediated injury that directly damages…
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Keywords:
age related;
related neurodegenerative;
disease;
brain ... See more keywords
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Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.07.004
Abstract: Abstract Aggregated alpha‐synuclein is the main component of Lewy bodies, intraneuronal inclusions found in brains with Parkinson's disease and dementia with Lewy bodies. A body of evidence implicates oxidative stress in the pathogenesis of these…
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Keywords:
different pathways;
hne;
molar excess;
oligomerization ... See more keywords
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Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.04.167
Abstract: Lipids are susceptible to damage by reactive species, and many lipid peroxidation products can be formed. 4-hydroxynonenal (HNE) is one of the most abundant and is known to form covalent adducts with proteins. Here we…
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Keywords:
anti hne;
hne treated;
human serum;
hne ... See more keywords
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Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.05.013
Abstract: Apoptosis of macrophage foam cells loaded with modified/oxidized lipids is implicated in destabilization of advanced atherosclerotic plaques in humans. Concentration of HNE, main aldehydic product of plasma LDL peroxidation, elevates in atherosclerotic lesions as well…
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Keywords:
apoptosis;
induced apoptosis;
ikk;
bcl ... See more keywords
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Published in 2020 at "Trends in Food Science and Technology"
DOI: 10.1016/j.tifs.2019.12.011
Abstract: Abstract Background Lipid peroxidation yields a large number of aldehydes and carbonyl-containing compounds, of which the reactive and toxic compound 4-hydroxy-2-nonenal (4-HNE) derived from ω-6 polyunsaturated fatty acids (ω-6 PUFAs) is the most extensively studied.…
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Keywords:
mitigation strategies;
hydroxy nonenal;
toxicity;
hne ... See more keywords