The increased expression of cytokeratin 13 leads to an increase in radiosensitivity of nasopharyngeal carcinoma HNE-3 cells by upregulating ERRFI1.
Sign Up to like & getrecommendations! Published in 2023 at "IUBMB life"
DOI: 10.1002/iub.2724
Abstract: The main factors contributing to the unfavorable outcome in the clinical treatment of patients with nasopharyngeal carcinoma (NPC) patients are radiation resistance and recurrence. This study aimed to investigate the sensitivity and molecular foundation of… read more here.
Keywords: cell; apoptosis; hne; expression ... See more keywords
l-Arginine prevents 4-hydroxy-2-nonenal accumulation and depresses inflammation via inhibiting NF-κB activation.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.23087
Abstract: 4-Hydroxy-2-nonenal (HNE) is an inducer of inflammation. The aim of this study was to elicit the link between the inhibition of HNE accumulation and the depression of inflammation whether dependent onl-arginine availability in growing rats.… read more here.
Keywords: activation; hydroxy nonenal; hne; arginine ... See more keywords
Enzymatic, structural, and biophysical characterization of a single‐domain antibody (VHH) selectively and tightly inhibiting neutrophil elastase and exhibiting favorable developability properties
Sign Up to like & getrecommendations! Published in 2024 at "Protein Science"
DOI: 10.1002/pro.5227
Abstract: Human neutrophil elastase (hNE), a serine protease released by neutrophils during inflammation, plays a major role in the pathophysiology of several conditions especially in inflammatory lung diseases. Its inhibition constitutes, therefore, a promising therapeutic strategy… read more here.
Keywords: structural biophysical; enzymatic structural; neutrophil elastase; hne ... See more keywords
Synthesis and evaluation of benzenesulfonic acid derivatives as human neutrophil elastase (hNE) inhibitors
Sign Up to like & getrecommendations! Published in 2021 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-020-02684-4
Abstract: Herein we report our investigation concerning the development of Human neutrophil elastase (hNE) inhibitors for the treatment of Acute Respiratory Distress Syndrome (ARDS). Various benzenesulfonic acid derived compounds were synthesized and evaluated as competitive inhibitors… read more here.
Keywords: benzenesulfonic acid; neutrophil elastase; human neutrophil; hne ... See more keywords
Linalool May Exert Neuroprotective Effects Against Cadmium-Induced Hippocampal Neurodegeneration by Regulating the 4-HNE/NF-κB Signaling Pathway
Sign Up to like & getrecommendations! Published in 2025 at "Biological Trace Element Research"
DOI: 10.1007/s12011-025-04734-7
Abstract: Cadmium (Cd) is a prevalent industrial and environmental contaminant that accumulates in the tissues of animals and humans. In particular, one of the regions most affected by Cd-induced neurodegeneration is the hippocampus. Linalool (Lin) is… read more here.
Keywords: hippocampal neurodegeneration; induced hippocampal; neuroprotective effects; neurodegeneration ... See more keywords
Survival Outcomes in Patients With RAS Wild Type Metastatic Colorectal Cancer Classified According to Köhne Prognostic Category and BRAF Mutation Status
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Colorectal Cancer"
DOI: 10.1016/j.clcc.2017.09.006
Abstract: Background: Köhne prognostic score is used to classify patients with metastatic colorectal cancer (mCRC) as high, intermediate, or low risk. Using data from 2 phase III trials, we analyzed survival in patients categorized according to… read more here.
Keywords: category braf; category; colorectal cancer; hne prognostic ... See more keywords
4-HNE induces proinflammatory cytokines of human retinal pigment epithelial cells by promoting extracellular efflux of HSP70.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental eye research"
DOI: 10.1016/j.exer.2019.107792
Abstract: Oxidative stress and subsequent chronic inflammation result in dysfunction of the retinal pigment epithelium (RPE) and represent therapeutic targets in the context of age-related macular degeneration (AMD). However, molecular mechanisms that linked oxidative stress and… read more here.
Keywords: hsp70; production; rpe cells; efflux ... See more keywords
Effect of 4-hydroxy-2-nonenal on myoglobin-mediated lipid oxidation when varying histidine content and hemin affinity.
Sign Up to like & getrecommendations! Published in 2017 at "Food chemistry"
DOI: 10.1016/j.foodchem.2017.01.035
Abstract: The compound 4-hydroxy-2-nonenal (HNE) dissolved in water was examined to remove potential effects of using ethanol to solubilize the aldehyde such as altering protein structure or redox properties of myoglobin (Mb). HNE became covalently bound… read more here.
Keywords: oxidation; mediated lipid; hemin affinity; hydroxy nonenal ... See more keywords
Role of 4‐hydroxy‐2‐nonenal (HNE) in the pathogenesis of alzheimer disease and other selected age‐related neurodegenerative disorders
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2016.10.490
Abstract: Abstract Oxidative stress is involved in various and numerous pathological states including several age‐related neurodegenerative diseases. Peroxidation of the membrane lipid bilayer is one of the major sources of free radical‐mediated injury that directly damages… read more here.
Keywords: age related; related neurodegenerative; disease; brain ... See more keywords
Low molar excess of 4‐oxo‐2‐nonenal and 4‐hydroxy‐2‐nonenal promote oligomerization of alpha‐synuclein through different pathways
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.07.004
Abstract: Abstract Aggregated alpha‐synuclein is the main component of Lewy bodies, intraneuronal inclusions found in brains with Parkinson's disease and dementia with Lewy bodies. A body of evidence implicates oxidative stress in the pathogenesis of these… read more here.
Keywords: different pathways; hne; molar excess; oligomerization ... See more keywords
Immunodetecting lipoxidation: epitope mapping of HNE-modified human serum albumin using two different anti-HNE pAbs
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.04.167
Abstract: Lipids are susceptible to damage by reactive species, and many lipid peroxidation products can be formed. 4-hydroxynonenal (HNE) is one of the most abundant and is known to form covalent adducts with proteins. Here we… read more here.
Keywords: anti hne; hne treated; human serum; hne ... See more keywords