Differential expression of HNF1A and HNF1A‐AS1 in colon cancer cells
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DOI: 10.1002/iub.2609
Abstract: The human hepatocyte nuclear factor 1 homeobox A (HNF1A) gene loci express the protein‐coding HNF1A transcript and a long non‐coding RNA in the anti‐sense (HNF1A‐AS1) direction. HNF1A‐AS1 is expressed in numerous types of cancers and… read more here.
Keywords: hnf1a hnf1a; hnf1a as1; rna; hnf1a ... See more keywords
Prognostic and clinical significance of long non-coding RNA HNF1A-AS1 in solid cancers
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DOI: 10.1097/md.0000000000018264
Abstract: Abstract Background: LncRNA HNF1A Antisense RNA 1 (HNF1A-AS1) is often dysregulated in cancer. We performed this meta-analysis to clarify the usefulness of HNF1A-AS1 as a prognostic marker in malignant tumors. Methods: The PubMed, OVID, and… read more here.
Keywords: hnf1a as1; as1 expression; hnf1a; rna hnf1a ... See more keywords
Metastable Reprogramming State of Single Transcription Factor-Derived Induced Hepatocyte-Like Cells
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DOI: 10.1155/2019/6937257
Abstract: We previously described the generation of induced hepatocyte-like cells (iHeps) using the hepatic transcription factor Hnf1a together with small molecules. These iHeps represent a hepatic state that is more mature compared with iHeps generated with… read more here.
Keywords: state; induced hepatocyte; hnf1a; hepatocyte like ... See more keywords
HNF1A-AS1：A tumor-associated long non-coding RNA.
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DOI: 10.2174/1381612828666220520113846
Abstract: BACKGROUND Hepatocyte nuclear factor 1 homeobox A antisense RNA 1 (HNF1A-AS1) is a Long non-coding RNA（LncRNA）that participates in the occurrence development of lots of tumors and is supposed to be a new biomarker. The text… read more here.
Keywords: hnf1a as1; rna; hnf1a; tumor ... See more keywords
Plasma Fucosylated Glycans and C-Reactive Protein as Biomarkers of HNF1A-MODY in Young Adult–Onset Nonautoimmune Diabetes
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DOI: 10.2337/dc18-0422
Abstract: OBJECTIVE Maturity-onset diabetes of the young (MODY) due to variants in HNF1A is the most common type of monogenic diabetes. Frequent misdiagnosis results in missed opportunity to use sulfonylureas as first-line treatment. A nongenetic biomarker… read more here.
Keywords: hnf1a; reactive protein; mody; hnf1a alleles ... See more keywords
Novel Loss-of-Function Variant in HNF1a Induces β-Cell Dysfunction through Endoplasmic Reticulum Stress
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DOI: 10.3390/ijms232113022
Abstract: Heterozygous variants in the hepatocyte nuclear factor 1a (HNF1a) cause MODY3 (maturity-onset diabetes of the young, type 3). In this study, we found a case of novel HNF1a p.Gln125* (HNF1a-Q125ter) variant clinically. However, the molecular… read more here.
Keywords: hnf1a; stress; function; hnf1a q125ter ... See more keywords
HNF1A regulates oxaliplatin resistance in pancreatic cancer by targeting 53BP1
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DOI: 10.3892/ijo.2023.5493
Abstract: DNA double-strand break repair is critically involved in oxaliplatin resistance in pancreatic ductal adenocarcinoma (PDAC). Hepatocyte nuclear factor 1 homeobox A (HNF1A) has received increased attention regarding its role in cancer progression. The present study… read more here.
Keywords: oxaliplatin resistance; resistance; hnf1a; pdac ... See more keywords
sh-HNF1A-AS1 reduces the epithelial-mesenchymal transition and stemness of esophageal cancer cells.
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DOI: 10.4149/neo_2022_211102n1555
Abstract: HNF1A-AS1 is a cancer-related lncRNA. Elevated expression of HNF1A-AS1 has been observed in various malignancies including esophageal squamous cell carcinoma (ESCC). However, the role of HNF1A-AS1 in ESCC has not been fully understood. This study… read more here.
Keywords: hnf1a as1; mir 298; stemness; expression ... See more keywords