Diagnosis of hepatic nuclear factor 1A monogenic diabetes mellitus (HNF1A-MODY) impacts antihyperglycemic treatment
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DOI: 10.1007/s00508-020-01770-2
Abstract: Monogenic mutations of the hepatocyte nuclear factor 1 homeobox A maturity onset diabetes of the young (HNF1A-MODY) is characterized by early onset, typically before the age of 25 years. Patients are often not clinically recognized; however, the… read more here.
Keywords: treatment; mody; diabetes mellitus; monogenic diabetes ... See more keywords
A decision algorithm to identify patients with high probability of monogenic diabetes due to HNF1A mutations
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DOI: 10.1007/s12020-019-01863-7
Abstract: PurposeTo investigate the utility of biomarkers of maturity-onset diabetes of the young (MODY), high-sensitivity C-reactive protein (hsCRP), and 1,5-anhydroglucitol (1,5-AG) in conjunction with other clinical and laboratory features to improve diagnostic accuracy and provide a… read more here.
Keywords: gck mody; mody; type diabetes; hscrp ... See more keywords
Liver Adenomatosis in Patients with HNF1A-Mody Diabetes: Clinical, Radiological and Pathological Characteristics in a French Series.
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DOI: 10.1111/1753-0407.12959
Abstract: BACKGROUND Liver adenomatosis (LA) is a rare disease resulting from biallelic inactivation of the HNF1A gene which induces the proliferation of adenoma cells in liver parenchyma. LA has only been documented in case reports from… read more here.
Keywords: liver adenomatosis; clinical radiological; radiological pathological; mody ... See more keywords
Insights from basic adjunctive examinations of GCK-MODY, HNF1A-MODY, and type 2 diabetes: A systemic review and meta-analysis.
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DOI: 10.1111/1753-0407.13390
Abstract: BACKGROUND Glucokinase maturity-onset diabetes of the young (GCK-MODY) is difficult to distinguish from other diabetic forms. This article aims to characterize the differences in results from routine examinations between GCK-MODY and hepatocyte nuclear factor 1-α… read more here.
Keywords: mody type; examinations gck; mody; gck mody ... See more keywords
1700-P: Association between Genetic Variation and Age of Onset of HNF1A MODY from the Expression Genetic Standpoint
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DOI: 10.2337/db19-1700-p
Abstract: HNF1A MODY is characterized by wide variability of the age of clinical manifestation. The aim of this study was to identify genes which expression would correlate with age of HNF1A-MODY onset in the skeletal muscle,… read more here.
Keywords: expression; hnf1a mody; age; none ... See more keywords
Plasma Fucosylated Glycans and C-Reactive Protein as Biomarkers of HNF1A-MODY in Young Adult–Onset Nonautoimmune Diabetes
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DOI: 10.2337/dc18-0422
Abstract: OBJECTIVE Maturity-onset diabetes of the young (MODY) due to variants in HNF1A is the most common type of monogenic diabetes. Frequent misdiagnosis results in missed opportunity to use sulfonylureas as first-line treatment. A nongenetic biomarker… read more here.
Keywords: hnf1a; reactive protein; mody; hnf1a alleles ... See more keywords
Novel insights into genetics and clinics of the HNF1A-MODY
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DOI: 10.2478/enr-2019-0013
Abstract: Abstract MODY (Maturity Onset Diabetes of the Young) is a type of diabetes resulting from a pathogenic effect of gene mutations. Up to date, 13 MODY genes are known. Gene HNF1A is one of the… read more here.
Keywords: genetics; mody; type diabetes; hnf1a mody ... See more keywords