Follistatin-controlled activin-HNF4α-coagulation factor axis in liver progenitor cells determines outcome of acute liver failure.
Sign Up to like & getrecommendations! Published in 2021 at "Hepatology"
DOI: 10.1002/hep.32119
Abstract: BACKGROUND & AIMS In patients with acute liver failure (ALF) who suffer from massive hepatocyte loss, liver progenitor cells (LPC) take over key hepatocyte functions, which ultimately determines survival. This study investigated how the expression… read more here.
Keywords: coagulation; liver failure; follistatin; hnf4 ... See more keywords
Nuclear receptor HNF4α performs a tumor suppressor function in prostate cancer via its induction of p21-driven cellular senescence
Sign Up to like & getrecommendations! Published in 2019 at "Oncogene"
DOI: 10.1038/s41388-019-1080-3
Abstract: Hepatocyte nuclear factor 4α (HNF4α, NR2A1) is a highly conserved member of the nuclear receptor superfamily. Recent advances reveal that it is a key transcriptional regulator of genes, broadly involved in xenobiotic and drug metabolism… read more here.
Keywords: cancer; cellular senescence; prostate cancer; hnf4 ... See more keywords
TGR5-HNF4α axis contributes to bile acid-induced gastric intestinal metaplasia markers expression
Sign Up to like & getrecommendations! Published in 2020 at "Cell Death Discovery"
DOI: 10.1038/s41420-020-0290-3
Abstract: Intestinal metaplasia (IM) increases the risk of gastric cancer. Our previous results indicated that bile acids (BAs) reflux promotes gastric IM development through kruppel-like factor 4 (KLF4) and caudal-type homeobox 2 (CDX2) activation. However, the… read more here.
Keywords: intestinal metaplasia; hnf4 axis; hnf4; acid ... See more keywords
A reinforcing HNF4-SMAD4 feed-forward module stabilizes enterocyte identity
Sign Up to like & getrecommendations! Published in 2019 at "Nature genetics"
DOI: 10.1038/s41588-019-0384-0
Abstract: BMP/SMAD signaling is a crucial regulator of intestinal differentiation1–4. However, the molecular underpinnings of the BMP pathway in this context are unknown. Here, we characterize the mechanism by which BMP/SMAD signaling drives enterocyte differentiation. We… read more here.
Keywords: hnf4 smad4; module; hnf4; stabilizes enterocyte ... See more keywords
A critical role for HNF4α in polymicrobial sepsis-associated metabolic reprogramming and death
Sign Up to like & getrecommendations! Published in 2024 at "EMBO Molecular Medicine"
DOI: 10.1038/s44321-024-00130-1
Abstract: In sepsis, limited food intake and increased energy expenditure induce a starvation response, which is compromised by a quick decline in the expression of hepatic PPARα, a transcription factor essential in intracellular catabolism of free… read more here.
Keywords: loss; acute phase; hnf4; phase response ... See more keywords
HNF4-alpha in hepatocyte health and disease.
Sign Up to like & getrecommendations! Published in 2023 at "Seminars in liver disease"
DOI: 10.1055/a-2097-0660
Abstract: Hepatocyte Nuclear Factor 4 alpha (HNF4α) is a highly conserved member of the nuclear receptor superfamily expressed at high levels in the liver, kidney, pancreas, and gut. In the liver, HNF4α is exclusively expressed in… read more here.
Keywords: hnf4 alpha; alpha hepatocyte; liver; disease ... See more keywords
#2272 HNF4a drives metabolic reprogramming in podocytes through ChREBP/SREBP-mediated pathway and promotes cell cycle progression
Sign Up to like & getrecommendations! Published in 2025 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfaf116.1334
Abstract: Metabolic adaptation of podocytes plays an important role in diabetic kidney disease (DKD) progression. Recent studies have highlighted the importance of metabolic regulation in maintaining podocyte function under diabetic stress conditions. While hepatocyte nuclear factor… read more here.
Keywords: cell cycle; progression; chrebp srebp; hnf4 ... See more keywords
HNF4α is possibly the missing link between epithelial–mesenchymal transition and Warburg effect during hepatocarcinogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Science"
DOI: 10.1111/cas.15686
Abstract: Hepatocellular carcinoma (HCC) is a heterogeneous, late‐diagnosed, and highly recurrent malignancy that often affects the whole body's metabolism. Finding certain theranostic molecules that can address current concerns simultaneously is one of the priorities in HCC… read more here.
Keywords: warburg effect; hnf4; epithelial mesenchymal; mesenchymal transition ... See more keywords
Conjugated Linoleic Acid Treatment Attenuates Cancerous features in Hepatocellular Carcinoma Cells
Sign Up to like & getrecommendations! Published in 2022 at "Stem Cells International"
DOI: 10.1155/2022/1850305
Abstract: Background A growing number of hepatocellular carcinoma (HCC), and recurrence frequency recently have drawn researchers' attention to alternative approaches. The concept of differentiation therapies (DT) relies on inducing differentiation in HCC cells in order to… read more here.
Keywords: hepatocellular carcinoma; conjugated linoleic; hcc cells; linoleic acid ... See more keywords
HNF4α-deficient Fatty Liver Provides a Permissive Environment for Sex-independent Hepatocellular Carcinoma.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer research"
DOI: 10.1158/0008-5472.can-19-1277
Abstract: The incidence of hepatocellular carcinoma (HCC) is on the rise worldwide. Although the incidence of HCC in males is considerably higher than in females, the projected rates of HCC incidence are increasing for both sexes.… read more here.
Keywords: incidence; hepatocellular carcinoma; hcc; fatty liver ... See more keywords
Functional Analysis of a Novel HNF4A Variant Identified in a Patient With MODY1
Sign Up to like & getrecommendations! Published in 2024 at "Journal of the Endocrine Society"
DOI: 10.1210/jendso/bvae090
Abstract: Abstract Context HNF4A–maturity-onset diabetes of the young (MODY1) is a relatively rare subtype of monogenic diabetes caused by loss of function of the HNF4A gene, which encodes the transcription factor HNF4α. HNF4α is known to… read more here.
Keywords: functional analysis; hnf4a variant; hnf4a; hnf4 ... See more keywords