TGR5-HNF4α axis contributes to bile acid-induced gastric intestinal metaplasia markers expression
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DOI: 10.1038/s41420-020-0290-3
Abstract: Intestinal metaplasia (IM) increases the risk of gastric cancer. Our previous results indicated that bile acids (BAs) reflux promotes gastric IM development through kruppel-like factor 4 (KLF4) and caudal-type homeobox 2 (CDX2) activation. However, the… read more here.
Keywords: intestinal metaplasia; hnf4 axis; hnf4; acid ... See more keywords
Long non-coding RNA SNHG16 regulates cell behaviors through miR-542-3p/HNF4α axis via RAS/RAF/MEK/ERK signaling pathway in pediatric neuroblastoma cells
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DOI: 10.1042/bsr20200723
Abstract: Abstract Neuroblastoma (NB) is an extracranial solid tumor in children with complex mechanism. Increasing reports indicated that long non-coding RNA (lncRNA) small nucleolar RNA host gene 16 (SNHG16) account for the pathogenesis of NB. Nevertheless,… read more here.
Keywords: 542 hnf4; mir 542; hnf4 axis; ras raf ... See more keywords