HNF4A Haploinsufficiency in MODY1 Abrogates Liver and Pancreas Differentiation from Patient-Derived Induced Pluripotent Stem Cells
Sign Up to like & getrecommendations! Published in 2019 at "iScience"
DOI: 10.1016/j.isci.2019.05.032
Abstract: Summary Maturity-onset diabetes of the young 1 (MODY1) is a monogenic diabetes condition caused by heterozygous HNF4A mutations. We investigate how HNF4A haploinsufficiency from a MODY1/HNF4A mutation influences the development of foregut-derived liver and pancreatic… read more here.
Keywords: haploinsufficiency mody1; hnf4a; hnf4a haploinsufficiency; pluripotent stem ... See more keywords
Therapeutic HNF4A mRNA attenuates liver fibrosis in a preclinical model.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of hepatology"
DOI: 10.1016/j.jhep.2021.08.011
Abstract: BACKGROUND AND AIMS Messenger RNA (mRNA)-based therapeutics are rapidly progressing to the clinic and hold tremendous potential for benefiting millions of people worldwide. Therapeutic targeting of injuries that require transient restoration of proteins by mRNA… read more here.
Keywords: hnf4a; fibrosis; liver fibrosis; fibrosis cirrhosis ... See more keywords
Hepatocyte nuclear factor 4A improves hepatic differentiation of immortalized adult human hepatocytes and improves liver function and survival
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2017.08.020
Abstract: Abstract Immortalized human hepatocytes (IHH) could provide an unlimited supply of hepatocytes, but insufficient differentiation and phenotypic instability restrict their clinical application. This study aimed to determine the role of hepatocyte nuclear factor 4A (HNF4A)… read more here.
Keywords: ihh; liver function; hnf4a; hepatic differentiation ... See more keywords
The transcription factor hepatocyte nuclear factor 4A acts in the intestine to promote white adipose tissue energy storage
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-021-27934-w
Abstract: The transcription factor hepatocyte nuclear factor 4 A (HNF4A) controls the metabolic features of several endodermal epithelia. Both HNF4A and HNF4G are redundant in the intestine and it remains unclear whether HNF4A alone controls intestinal lipid… read more here.
Keywords: factor hepatocyte; transcription factor; energy; hnf4a ... See more keywords
A cross-species approach to identify transcriptional regulators exemplified for Dnajc22 and Hnf4a
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-04370-9
Abstract: There is an enormous need to make better use of the ever increasing wealth of publicly available genomic information and to utilize the tremendous progress in computational approaches in the life sciences. Transcriptional regulation of… read more here.
Keywords: transcription; publicly available; hnf4a; cross species ... See more keywords
AODTH-010 A mirna-epigenetic network in pancreatic cancer
Sign Up to like & getrecommendations! Published in 2017 at "Gut"
DOI: 10.1136/gutjnl-2017-314472.397
Abstract: Introduction The dismal prognosis of pancreatic cancer due to the delayed diagnosis, rapid metastasis and resistance to current therapeutics, signifies the importance of identifying novel therapeutic approaches. Although the past two decades of research have… read more here.
Keywords: hnf4a; dna; pancreatic cancer; expression ... See more keywords
Intestinal epithelial transcription factor HNF4A protects against microbiota dependent colitis and expansion of Akkermansia muciniphila
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5734521
Abstract: Development of the inflammatory bowel diseases (IBD) has been linked to altered homeostatic relationships between the intestine and the microbiota it harbors. However early preclinical stages of IBD remain poorly understood, especially with respect to… read more here.
Keywords: microbiota; hnf4a; iec mice; hnf4a iec ... See more keywords
HNF4A Regulates the Proliferation and Tumor Formation of Cervical Cancer Cells through the Wnt/β-Catenin Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/8168988
Abstract: Hepatocyte nuclear factor 4 alpha (HNF4A) is a transcriptional factor which plays an important role in the development of the liver, kidney, and intestines. Nevertheless, its role in cervical cancer and the underlying mechanism remain… read more here.
Keywords: cervical cancer; cancer; hnf4a; wnt catenin ... See more keywords
ABAT and ALDH6A1, regulated by transcription factor HNF4A, suppress tumorigenic capability in clear cell renal cell carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-020-02268-1
Abstract: Background Clear cell renal cell carcinoma (ccRCC) is a malignancy characterized by metabolic reprogramming. ABAT and ALDH6A1 are metabolic enzymes. In this study, we aim to investigate the associations of ABAT and ALDH6A1 with the… read more here.
Keywords: abat; abat aldh6a1; clear cell; hnf4a ... See more keywords
HNF4A expression as a potential diagnostic tool to discriminate primary gastric cancer from breast cancer metastasis in a Brazilian cohort
Sign Up to like & getrecommendations! Published in 2017 at "Diagnostic Pathology"
DOI: 10.1186/s13000-017-0635-2
Abstract: BackgroundAmong the many challenges in cancer diagnosis is the early distinction between metastatic cancer and a secondary tumor. This difficulty stems from the lack of markers that offer high sensitivity and specificity and can be… read more here.
Keywords: hnf4a; gastric cancer; primary gastric; breast cancer ... See more keywords
HNF4A-related Fanconi syndrome in a Chinese patient: a case report and review of the literature
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Medical Case Reports"
DOI: 10.1186/s13256-018-1740-x
Abstract: BackgroundThe p.R63W mutation in hepatocyte nuclear factor-4 alpha (HNF4A) leads to a heterogeneous group of disorders with various clinical presentations. Recently, patients with congenital hyperinsulinism and Fanconi syndrome due to the p.R63W mutation in HNF4A… read more here.
Keywords: mutation; hnf4a; fanconi syndrome; case report ... See more keywords