HNF4A Haploinsufficiency in MODY1 Abrogates Liver and Pancreas Differentiation from Patient-Derived Induced Pluripotent Stem Cells
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DOI: 10.1016/j.isci.2019.05.032
Abstract: Summary Maturity-onset diabetes of the young 1 (MODY1) is a monogenic diabetes condition caused by heterozygous HNF4A mutations. We investigate how HNF4A haploinsufficiency from a MODY1/HNF4A mutation influences the development of foregut-derived liver and pancreatic… read more here.
Keywords: haploinsufficiency mody1; hnf4a; hnf4a haploinsufficiency; pluripotent stem ... See more keywords