Pharmacological evaluation of clinically relevant concentrations of (2R,6R)-hydroxynorketamine
Sign Up to like & getrecommendations! Published in 2019 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2019.04.019
Abstract: Ketamine is a rapid-onset antidepressant whose efficacy long outlasts its pharmacokinetics. Multiple studies suggest ketamine's antidepressant effects require increased α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR)-dependent currents, which have recently been exclusively attributed to its N-methyl-d-aspartate receptor-inactive metabolite… read more here.
Keywords: hnk concentrations; clinically antidepressant; ketamine; pharmacological evaluation ... See more keywords
Hydroxynorketamine Pharmacokinetics and Antidepressant Behavioral Effects of (2,6)- and (5R)-Methyl-(2R,6R)-hydroxynorketamines.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.1c00761
Abstract: (R,S)-Ketamine is rapidly metabolized to form a range of metabolites in vivo, including 12 unique hydroxynorketamines (HNKs) that are distinguished by a cyclohexyl ring hydroxylation at the 4, 5, or 6 position. While both (2R,6R)-… read more here.
Keywords: potency; cyclohexanone ring; hydroxynorketamine pharmacokinetics; pharmacokinetics antidepressant ... See more keywords
Ketamine and its metabolite (2R,6R)-hydroxynorketamine induce lasting alterations in glutamatergic synaptic plasticity in the mesolimbic circuit
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Psychiatry"
DOI: 10.1038/mp.2017.239
Abstract: Low doses of ketamine trigger rapid and lasting antidepressant effects after one injection in treatment-resistant patients with major depressive disorder. Modulation of AMPA receptors (AMPARs) in the hippocampus and prefrontal cortex is suggested to mediate… read more here.
Keywords: plasticity mesolimbic; hydroxynorketamine; ketamine; synaptic plasticity ... See more keywords
Zanos et al. reply
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/nature22085
Abstract: Clinical data have demonstrated rapid and sustained antidepressant effects of ketamine, a noncompetitive NMDAR (N-methyl-daspartate receptor) antagonist1. Recently, Zanos et al.2 claimed that the ketamine metabolite (2R,6R)-hydroxynorketamine (HNK) is essential for the antidepressant effects of… read more here.
Keywords: zanos reply; ampar; hnk; factor ... See more keywords
Cognitive Signaling in Cerebellar Granule Cells
Sign Up to like & getrecommendations! Published in 2018 at "Neuropsychopharmacology"
DOI: 10.1038/npp.2017.186
Abstract: ketamine’s dissociative side effects and abuse potential has led to the search for identification of alternative compounds that trigger rapid antidepressant effects without the psychotomimetic side effects. A successful effort will require elucidation of the… read more here.
Keywords: nmdar; ketamine; signaling pathway; hnk ... See more keywords
(2R,6R)-Hydroxynorketamine is not essential for the antidepressant actions of (R)-ketamine in mice
Sign Up to like & getrecommendations! Published in 2018 at "Neuropsychopharmacology"
DOI: 10.1038/s41386-018-0084-y
Abstract: Abstract(R,S)-Ketamine has rapid and sustained antidepressant effects in depressed patients. Although the metabolism of (R,S)-ketamine to (2 R,6 R)-hydroxynorketamine (HNK), a metabolite of (R)-ketamine, has been reported to be essential for its antidepressant effects, recent evidence suggests… read more here.
Keywords: ketamine; antidepressant actions; essential antidepressant; hnk ... See more keywords
(2R,6R)-Hydroxynorketamine (HNK) plasma level predicts poor antidepressant response: is this the end of the HNK pipeline?
Sign Up to like & getrecommendations! Published in 2020 at "Neuropsychopharmacology"
DOI: 10.1038/s41386-020-0668-1
Abstract: In 2016, the finding that (2R,6R)-hydroxynorketamine (HNK) may possess antidepressant properties took the field by surprise [1]. A set of outstanding preclinical studies questioned the role of N-methyl-D-aspartate receptor (NMDAR) in ketamine’s rapidacting antidepressant (RAAD)… read more here.
Keywords: response; hnk plasma; ketamine; level ... See more keywords
Sex-specific neurobiological actions of prophylactic (R,S)-ketamine, (2R,6R)-hydroxynorketamine, and (2S,6S)-hydroxynorketamine
Sign Up to like & getrecommendations! Published in 2020 at "Neuropsychopharmacology"
DOI: 10.1038/s41386-020-0714-z
Abstract: Enhancing stress resilience in at-risk populations could significantly reduce the incidence of stress-related psychiatric disorders. We have previously reported that the administration of (R,S)-ketamine prevents stress-induced depressive-like behavior in male mice, perhaps by altering α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic… read more here.
Keywords: hydroxynorketamine; ketamine; stress induced; stress ... See more keywords
Liposomal Honokiol induces ROS-mediated apoptosis via regulation of ERK/p38-MAPK signaling and autophagic inhibition in human medulloblastoma
Sign Up to like & getrecommendations! Published in 2022 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-021-00869-w
Abstract: Dear Editor, Nowadays, medulloblastoma accounts for approximately 25% of all pediatric brain tumors. Even with the successful treatment of primary tumors, there are still serious side effects. Honokiol (HNK) is defined as small bisphenol lignin… read more here.
Keywords: hnk; apoptosis; supplementary fig; lip hnk ... See more keywords
Intravenous Honokiol in Drug-Resistant Cancer: Two Case Reports
Sign Up to like & getrecommendations! Published in 2020 at "Integrative Cancer Therapies"
DOI: 10.1177/1534735420922615
Abstract: Context: Long-term patient survival in cancer is affected by drug resistance. Honokiol (HNK) is a small-molecule polyphenol isolated from the bark and seed cones of Magnolia officinalis. HNK has been shown to enhance the effects… read more here.
Keywords: case; drug; drug resistant; intravenous honokiol ... See more keywords
Honokiol Inhibits HIF-1α-Mediated Glycolysis to Halt Breast Cancer Growth
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.796763
Abstract: Background: Hypoxia-inducible factor-1α (HIF-1α) induces the expression of glycolysis-related genes, which plays a direct and key role in Warburg effect. In a recent study, honokiol (HNK) was identified as one of the potential agents that… read more here.
Keywords: mediated glycolysis; hnk; hif; glycolysis ... See more keywords