(2R,6R)-Hydroxynorketamine (HNK) plasma level predicts poor antidepressant response: is this the end of the HNK pipeline?
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DOI: 10.1038/s41386-020-0668-1
Abstract: In 2016, the finding that (2R,6R)-hydroxynorketamine (HNK) may possess antidepressant properties took the field by surprise [1]. A set of outstanding preclinical studies questioned the role of N-methyl-D-aspartate receptor (NMDAR) in ketamine’s rapidacting antidepressant (RAAD)… read more here.
Keywords: response; hnk plasma; ketamine; level ... See more keywords