Microglia actively remove NR1 autoantibody-bound NMDA receptors and associated post-synaptic proteins in neuron microglia co-cultures.
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DOI: 10.1002/glia.24369
Abstract: Autoantibodies against the NR1 subunit of NMDA receptors (NMDARs) have been shown to promote crosslinking and internalization of bound receptors in NMDAR encephalitis (NMDARE). This internalization-mediated loss of NMDARs is thought to be the major… read more here.
Keywords: nr1 autoantibody; nmda receptors; autoantibody; synaptic proteins ... See more keywords