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   Articles with "hnrnp" as a keyword



Testis‐specific hnRNP is expressed in colorectal cancer cells and accelerates cell growth mediating ZDHHC11 mRNA stabilization

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recommendations! Published in 2022 at "Cancer Medicine"

DOI: 10.1002/cam4.4738

Abstract: Various heterogeneous nuclear ribonucleoproteins (hnRNPs) have been reported to be associated with cancer cell growth. However, it remains unclear whether hnRNP G‐T, which is specifically expressed in the testis, is expressed in tumor cells, and… read more here.

Keywords: hnrnp; cell growth; cancer; zdhhc11 mrna ... See more keywords

Heterogeneous nuclear ribonucleoprotein A3 binds to the internal ribosomal entry site of enterovirus A71 and affects virus replication in neural cells.

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recommendations! Published in 2024 at "Journal of cellular biochemistry"

DOI: 10.1002/jcb.30575

Abstract: Enterovirus A71 (EV-A71) belongs to the genus Enterovirus of the Picornaviridae family and often causes outbreaks in Asia. EV-A71 infection usually causes hand, foot, and mouth disease and can even affect the central nervous system,… read more here.

Keywords: replication; hnrnp; heterogeneous nuclear; entry site ... See more keywords

The role of the heterogeneous nuclear ribonucleoprotein (hnRNP) Hrb27C in regulating lipid storage in the Drosophila fat body.

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recommendations! Published in 2020 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2020.01.064

Abstract: The storage of excess nutrients as triglycerides is essential for all organisms to survive when food is scarce; however, the mechanisms by which triglycerides are stored are not completely understood. Genome-wide RNAi screens in Drosophila… read more here.

Keywords: storage; fat body; hnrnp; hrb27c ... See more keywords

NMR Studies of Conformational Selection of hnRNP H on RNA Splicing

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recommendations! Published in 2017 at "Biophysical Journal"

DOI: 10.1016/j.bpj.2016.11.1877

Abstract: Modularity provides proteins versatility in regulating many cellular processes. The RNA Recognition Motif (RRM) is a common protein family that adopts modularity to facilitate its biological activity. hnRNP H contains three RRMs that play important… read more here.

Keywords: conformational selection; hnrnp; form; closed form ... See more keywords

HnRNP-F regulates EMT in bladder cancer by mediating the stabilization of Snail1 mRNA by binding to its 3′ UTR

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recommendations! Published in 2019 at "EBioMedicine"

DOI: 10.1016/j.ebiom.2019.06.017

Abstract: Background Heterogeneous nuclear ribonucleoprotein F (hnRNP-F) has been implicated in multiple cancers, suggesting its role in tumourigenesis, but the potential oncogenic role and mechanism of hnRNP-F in bladder cancer (BC) remain incompletely understood. Methods HnRNP-F… read more here.

Keywords: stabilization snail1; bladder cancer; hnrnp; snail1 mrna ... See more keywords

The effect of O‐GlcNAcylation on hnRNP A1 translocation and interaction with transportin1

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recommendations! Published in 2017 at "Experimental Cell Research"

DOI: 10.1016/j.yexcr.2016.11.023

Abstract: Abstract The heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) is a major pre‐mRNA binding protein involved in transcription and translation. Although predominantly nuclear, hnRNP A1 shuttles rapidly between the nucleus and the cytosol, delivering its anchored… read more here.

Keywords: hnrnp; glcnacylation; interaction; hnrnp translocation ... See more keywords

Sirtuin-mediated deacetylation of hnRNP A1 suppresses glycolysis and growth in hepatocellular carcinoma

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recommendations! Published in 2019 at "Oncogene"

DOI: 10.1038/s41388-019-0764-z

Abstract: Tumor cells undergo a metabolic shift in order to adapt to the altered microenvironment, although the underlying mechanisms have not been fully explored. HnRNP A1 is involved in the alternative splicing of the pyruvate kinase… read more here.

Keywords: hepatocellular carcinoma; hnrnp; glycolysis; hcc cells ... See more keywords

Strand-specific affinity of host factor hnRNP C1/C2 guides positive to negative-strand ratio in Coxsackievirus B3 infection

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recommendations! Published in 2019 at "RNA Biology"

DOI: 10.1080/15476286.2019.1629208

Abstract: ABSTRACT Coxsackievirus B3 is an enterovirus, with positive-sense single-stranded RNA genome containing ‘Internal Ribosome Entry Site’ (IRES) in the 5ʹUTR. Once sufficient viral proteins are synthesized in the cell from the input RNA, viral template… read more here.

Keywords: positive negative; hnrnp; strand; negative strand ... See more keywords

Identification of RNA-binding protein hnRNP C targeting the 3’UTR of the TAP-associated glycoprotein tapasin in melanoma

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recommendations! Published in 2024 at "Oncoimmunology"

DOI: 10.1080/2162402x.2024.2370928

Abstract: ABSTRACT Deregulation or loss of the human leukocyte antigen class I (HLA-I) molecules on tumor cells leading to inhibition of CD8+ T cell recognition is an important tumor immune escape strategy, which could be caused… read more here.

Keywords: hnrnp; associated glycoprotein; tap associated; glycoprotein tapasin ... See more keywords

The hnRNP C tetramer binds to CBC on mRNA and impedes PHAX recruitment for the classification of RNA polymerase II transcripts

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recommendations! Published in 2023 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkac1250

Abstract: Abstract In eukaryotic cells, various classes of RNAs are exported to the cytoplasm by class-specific factors. Accumulating evidence has shown that export factors affect the fate of RNA, demonstrating the importance of proper RNA classification… read more here.

Keywords: classification; hnrnp; rna polymerase; rna ... See more keywords

hnRNP G/RBMX enhances HPV16 E2 mRNA splicing through a novel splicing enhancer and inhibits production of spliced E7 oncogene mRNAs

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recommendations! Published in 2022 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkac213

Abstract: Abstract Human papillomavirus type 16 (HPV16) E2 is an essential HPV16 protein. We have investigated how HPV16 E2 expression is regulated and have identifed a splicing enhancer that is required for production of HPV16 E2… read more here.

Keywords: hnrnp; production; hpv16 mrna; mrna splicing ... See more keywords