Clinical heterogeneity in a family with flail arm syndrome and review of hnRNPA1‐related spectrum
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51682
Abstract: Flail arm syndrome (FAS) is one of the atypical subtypes of amyotrophic lateral sclerosis (ALS). Mutations in hnRNPA1 encoding heterogeneous nuclear ribonucleoprotein (hnRNP) A1 are a rare genetic cause of ALS. Herein, marked clinical heterogeneity… read more here.
Keywords: review hnrnpa1; clinical heterogeneity; arm syndrome; hnrnpa1 related ... See more keywords
Heterogeneous nuclear ribonucleoprotein A1 promotes the expression of autophagy-related protein 6 in human colorectal cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.03.179
Abstract: Autophagy, a lysosomal self-degradative process of cellular components, is essential for cellular homeostasis to response cellular stress and is tightly controlled by autophagy-related genes (ATGs). Autophagy-related gene 6 (ATG6, also known as Beclin-1 in human)… read more here.
Keywords: nuclear ribonucleoprotein; promotes expression; expression; autophagy related ... See more keywords
Identification of an mRNA isoform switch for HNRNPA1 in breast cancers
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-04007-y
Abstract: Roles of HNRNPA1 are beginning to emerge in cancers; however, mechanisms causing deregulation of HNRNPA1 function remain elusive. Here, we describe an isoform switch between the 3′-UTR isoforms of HNRNPA1 in breast cancers. We show… read more here.
Keywords: breast; isoform switch; breast cancers; isoform ... See more keywords
Post-transcriptional control of KRAS: functional roles of 5′UTR RNA G-quadruplexes, long noncoding RNA, and hnRNPA1
Sign Up to like & getrecommendations! Published in 2025 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaf886
Abstract: Abstract Previous studies have shown that human KRAS expression is regulated at the transcriptional level by G-quadruplex DNA structures within its promoter. Here we show an additional level of regulation involving a post-transcriptional mechanism centred… read more here.
Keywords: kras mrna; hnrnpa1; rna; long noncoding ... See more keywords
Overexpression of c-Myc-dependent heterogeneous nuclear ribonucleoprotein A1 promotes proliferation and inhibits apoptosis in NOTCH1-mutated chronic lymphocytic leukemia cells
Sign Up to like & getrecommendations! Published in 2022 at "Chinese Medical Journal"
DOI: 10.1097/cm9.0000000000002037
Abstract: Abstract Background: NOTCH1 mutation is an essential molecular biologic aberration in chronic lymphocytic leukemia (CLL). CLL patients with NOTCH1 mutation have shown an unfavorable survival and a poor response to chemoimmunotherapy. This study aims to… read more here.
Keywords: proliferation; notch1 mutation; expression; hnrnpa1 ... See more keywords
Abstract We136: HnRNPA1 Modulates Expression of Myogenic Differentiation Factors by Maintenance of Ppp1r1b - lncRNA /PRC2 Complex Integrity
Sign Up to like & getrecommendations! Published in 2024 at "Circulation Research"
DOI: 10.1161/res.135.suppl_1.we136
Abstract: Objective: HnRNPA1 is an important member of the HNRNP family, serves multiple functions. The long noncoding RNA Ppp1r1b is a key regulator of myogenesis in cardiac and skeletal muscle development. This study aimed to investigate… read more here.
Keywords: hnrnpa1; ppp1r1b; ppp1r1b lncrna; lncrna prc2 ... See more keywords
The Splicing Factor hnRNPA1 Regulates Alternate Splicing of the MYLK Gene
Sign Up to like & getrecommendations! Published in 2018 at "American Journal of Respiratory Cell and Molecular Biology"
DOI: 10.1165/rcmb.2017-0141oc
Abstract: &NA; Profound lung vascular permeability is a cardinal feature of acute respiratory distress syndrome (ARDS) and ventilator‐induced lung injury (VILI), two syndromes known to centrally involve the nonmuscle isoform of myosin light chain kinase (nmMLCK)… read more here.
Keywords: splicing factor; mylk; mylk splicing; role ... See more keywords
Regulatory role of resveratrol, a microRNA-controlling compound, in HNRNPA1 expression, which is associated with poor prognosis in breast cancer
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.25339
Abstract: Certain lifestyles, such as unhealthy eating habits, are associated with an increased risk for several diseases, including cancer. Recently, some naturally occurring compounds, such as resveratrol, have been shown to regulate microRNA (miRNA) expression in… read more here.
Keywords: resveratrol; mir; breast cancer; expression ... See more keywords
Downregulation of hnRNPA1 inhibits hepatocellular carcinoma cell progression by modulating alternative splicing of ZNF207 exon 9
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2024.1517459
Abstract: Introduction Hepatocellular carcinoma (HCC) is the most prevalent liver cancer and a leading cause of cancer-related deaths worldwide. Heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) plays a critical role in RNA metabolism, including alternative splicing, which is… read more here.
Keywords: znf207; alternative splicing; hnrnpa1; progression ... See more keywords
LINC00114 promotes colorectal cancer metastasis by targeting HNRNPA1 to regulate glutamine metabolism reprogramming and angiogenesis
Sign Up to like & getrecommendations! Published in 2025 at "Acta Biochimica et Biophysica Sinica"
DOI: 10.3724/abbs.2025141
Abstract: Colorectal cancer (CRC) is a common type of gastrointestinal malignancy, and it has a close connection with long noncoding RNAs (lncRNAs). This study aims to examine the involvement of long noncoding RNA LINC00114, which targets… read more here.
Keywords: glutamine metabolism; linc00114; crc; hnrnpa1 ... See more keywords