Sustained transgene expression from sleeping beauty DNA transposons containing a core fragment of the HNRPA2B1-CBX3 ubiquitous chromatin opening element (UCOE)
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DOI: 10.1186/s12896-019-0570-2
Abstract: BackgroundDNA transposon-based vectors are effective nonviral tools for gene therapy and genetic engineering of cells. However, promoter DNA methylation and a near-random integration profile, which can result in transgene integration into heterochromatin, renders such vectors… read more here.
Keywords: hnrpa2b1 cbx3; core fragment; ucoe; transgene expression ... See more keywords